Metformin inhibits the production of reactive oxygen species from NADH: Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages
Citation:
LUKE O'NEILL, 'Metformin inhibits the production of reactive oxygen species from NADH: Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages', 2015, Journal of Biological Chemistry;, 290;, 33;Download Item:
J. Biol. Chem.-2015-Kelly-20348-59.pdf (PDF) 1.780Mb
Abstract:
Background: The antidiabetic drug and mitochondrial NADH:ubiquinone oxidoreductase (complex I) inhibitor metformin has anti-inflammatory activity. Results: Complex I inhibition decreases LPS-induced IL-1β and boosts IL-10. Mitochondrial ROS may be a signal driving LPS-induced IL-1β. Conclusion: Complex I has a role in the induction of cytokines by LPS. Significance: This study provides insight into the anti-inflammatory action of metformin and reveals a role for complex I dysfunction in inflammatory signaling
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Science Foundation Ireland
Author's Homepage:
http://people.tcd.ie/laoneill
Author: O'NEILL, LUKE
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Journal ArticleCollections:
Series/Report no:
Journal of Biological Chemistry;290;
33;
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antidiabetic drugDOI:
http://dx.doi.org/10.1074/jbc.M115.662114Licences: