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Next generation sequencing of ancient DNA
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)
The application of next generation sequencing (NGS) technologies into the
field of ancient DNA has seen a paradime shift in the level of analysis that can
be completed using archaeological samples. However, to fully access ...
Surface proteins and restriction-modification systems of bovine mastitis strains of Staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)
Staphylococcus aureus is frequently associated with bovine mastitis, one of the
most economically important diseases in the dairy industry. The bovine S. aureus strain
RF122 represents a geographically widespread clone ...
Characterisation of the second binding protein of immunoglobulin (SBi) in Straphylococcus aureus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)
The second binding protein for immunoglobulin (Sbi) of Staphylococcus aureus
comprises two IgG binding domains (D1 and D2) that share 30% sequence homology
with the IgG binding domains of protein A (Spa) and two domains ...
Rational design of artificial genetic switches : co-option of H-NS-repressed operons by the VirB virulence master regulator
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)
The H-NS protein represses the transcription of hundreds of genes in Gram-negative
bacteria. De-repression is achieved by a multitude of mechanisms, many of which
involve binding of a protein to DNA at the repressed promoter ...
Expression of hns and stpA in Salmonella enterica servoar Typhimurium
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)
H-NS-like proteins are widespread amongst Enterobacteriaceae and other Gramnegative bacteria. They are small (15 kDa) nucleoid associated proteins involved in many cellular processes such as replication, transposition, ...
Iron regulated surface determinants of Staphylococcus aureus and S. lugdunensis : their roles in pathogen-host interactions
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)
Staphylococcus aureus is a human pathogen that causes invasive infections.
The ability to internalize into and persist within host cells is thought to contribute to
pathogenesis. The study described here has identified a ...
From single nucleotide polymorphisms to high-throughput sequencing in the complex genetics of amyotrophic lateral sclerosis
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
progressive weakening of limb and bulbar muscles resulting in paralysis and death from
respiratory failure within three to five years ...
Staphylococcus lugdunensis : Genome sequence, genetic systems, virulence and an amplifiable isd locus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)
Staphylococcus lugdunensis is a coagulase negative staphylococcus
(CoNS). Infections caused by CoNS are normally less severe than infections
caused by S. aureus. However, S. lugdunensis is associated with a series of
severe ...
Sustained expression of fis, the gene coding for the Fis nucleoid-associated protein, during the stationary phase of growth in Salmonella enterica
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)
The Factor for Inversion Stimulation (Fis) is a global regulator of virulence genes in
Salmonella enterica serovar Typhimurium. Previously, the Fis protein was throught to be
expressed only during the early exponential ...
Evolution of the OmpR regulon in Salmonella enterica serovar Typhimurium and Escherichia coli in response to low pH
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)
Two-component systems (TCS) enable bacteria to sense, respond and adapt to a wide
range of environmental stimuli. The OmpR/EnvZ TCS is composed of the inner
membrane sensor kinase EnvZ and the response regulator OmpR. In ...