Browsing Microbiology by Author "FOSTER, TIMOTHY JAMES"
Now showing items 1-12 of 12
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The A domain of fibronectin-binding protein B of Staphylococcus aureus contains a novel fibronectin binding site.
FOSTER, TIMOTHY JAMES (2011)The fibronectin‐binding proteins FnBPA and FnBPB are multifunctional adhesins than can also bind to fibrinogen and elastin. In this study, the N2N3 subdomains of region A of FnBPB were shown to bind fibrinogen with a similar ... -
Activation of plasminogen by staphylokinase reduces the severity of Staphylococcus aureus systemic infection
FOSTER, TIMOTHY JAMES (2010)Background. Staphylokinase (SAK) is produced by the majority of Staphylococcus aureus strains. It is an extracellular protein that activates the conversion of human plasminogen (plg) to plasmin. The role played by SAK in ... -
Beta-neurexin is a ligand for the Staphylococcus aureus MSCRAMM SdrC
FOSTER, TIMOTHY JAMES (2010)Gram-positive bacteria contain a family of surface proteins that are covalently anchored to the cell wall of the organism. These cell-wall anchored (CWA) proteins appear to play key roles in the interactions between ... -
Fibrinogen binding sites P336 and Y338 of clumping factor A are crucial for Staphylococcus aureus virulence.
FOSTER, TIMOTHY JAMES (2008)We have earlier shown that clumping factor A (ClfA), a fibrinogen binding surface protein of Staphylococcus aureus, is an important virulence factor in septic arthritis. When two amino acids in the ClfA molecule, P336 and ... -
Functional analysis of a murine monoclonal antibody against the repetitive region of the fibronectin-binding adhesins fibronectin-binding protein A and fibronectin-binding protein B from Staphylococcus aureus.
FOSTER, TIMOTHY JAMES; GEOGHEGAN, JOAN (2010)Fibronectin-binding proteins A and B are multifunctional LPXTG staphylococcal adhesins, comprising an N-terminal region that binds fibrinogen and elastin, and a C-terminal domain that interacts with fibronectin. The ... -
Genetic analysis of gentamicin resistance in methicillin- and gentamicin-resistant strains of Staphylococcus aureus isolated in Dublin hospitals.
FOSTER, TIMOTHY JAMES (American Society for MIcrobiology, 1988)Methicillin- and gentamicin-resistant strains of Staphylococcus aureus isolated in Dublin hospitals have been classified into groups I, II, and III based on resistance to antimicrobial agents and plasmid profiles. Each ... -
Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMMS) ClfA and Fbl with fibrinogen
GEOGHEGAN, JOAN; FOSTER, TIMOTHY JAMES (2010)The ligand binding domain of the fibrinogen binding protein from Staphylococcus lugdunensis (Fbl) shares 60% sequence identity with clumping factor A (ClfA) of Staphylococcus aureus. Recombinant Fbl corresponding to the ... -
A novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, FnBPA and FnBPB.
FOSTER, TIMOTHY JAMES (2008)Device-associated infections involving biofilm remain a persistent clinical problem. We recently reported that four methicillin-resistant Staphylococcus aureus (MRSA)strains formed biofilm independently of the icaADBC-encoded ... -
A potential new pathway for Staphylococcus aureus dissemination: silent survival of S.aureus phagocytosed by human monocyte-derived macrophages.
FOSTER, TIMOTHY JAMES (2008)Although considered to be an extracellular pathogen, Staphylococcus aureus is able to invade a variety of mammalian, non-professional phagocytes and can also survive engulfment by professional phagocytes such as neutrophils ... -
Staphylococci and staphylococcal infections
FOSTER, TIMOTHY JAMES (2010)The International Symposium of Staphylococci and Staphylococcal Infections is a biennial conference that brings together clinicians who treat staphylococcal infections in the community and in hospitals, veterinary ... -
The Staphylococcus aureus "superbug"
FOSTER, TIMOTHY JAMES (2004)There has been some debate about the disease-invoking potential of Staphylococcus aureus strains and whether invasive disease is associated with particularly virulent genotypes, or "superbugs." A study in this issue of the ... -
Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic.
FOSTER, TIMOTHY JAMES; GEOGHEGAN, JOAN (2012)Similar to other highly successful invasive bacterial pathogens, Staphylococcus aureus recruits the complement regulatory protein factor H (fH) to its surface to inhibit the alternative pathway of complement. Here, we ...