Investigating the effect of solubility and density gradients on local hydrodynamics and drug dissolution in the USP 4 dissolution apparatus
Citation:
Deirdre M. D'Arcy, Bo Liu, Owen I. Corrigan, Investigating the effect of solubility and density gradients on local hydrodynamics and drug dissolution in the USP 4 dissolution apparatus, International Journal of Pharmaceutics, 419, 1-2, 2011, 175-185Download Item:
Investigating the effect of solubility and density gradients on local hydrodynamics and drug dissolution in the USP 4 dissolution apparatus.pdf (Published (author's copy) - Peer Reviewed) 734.5Kb
Abstract:
The aim of this investigation was to evaluate the effect of solubility and related solution density gradients, on hydrodynamics and dissolution rate in a low velocity pulsing flow, in the USP 4 flow-through dissolution apparatus. The paddle apparatus, flow-through apparatus and a free convection system were used in dissolution testing, using Benzoic Acid (BA) and Lactose Monohydrate (LM), representing slightly and freely soluble model compounds, respectively. A flow rate of 8 ml min?1 (22.6 mm diameter cell) was used in the flow-through apparatus. Computational fluid dynamics (CFD) simulations were used to analyze the effect of the dissolved compounds on local hydrodynamics. A higher dissolution rate of both BA and LM was obtained in the free convection system compared to the flow-through apparatus, with highest dissolution rate from both compounds in the paddle apparatus. The effect of downward flow arising from natural convection had a significant effect for the more soluble compound, LM, on local fluid velocities, whereas flow reversal induced by the forced convection environment was a significant feature impacting on the hydrodynamics in the BA species transfer simulation. The effect of solution density on local hydrodynamics needs to be considered when selecting dissolution conditions in the USP 4 dissolution apparatus.
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Grant Number
Irish Research Council for Science and Engineering Technology (IRCSET)
Author's Homepage:
http://people.tcd.ie/ocorrignhttp://people.tcd.ie/ddarcy
Description:
PUBLISHEDType of material:
Journal ArticleSeries/Report no:
International Journal of Pharmaceutics419
1-2
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Full text availableKeywords:
Pharmacology, computational fluid dynamics (CFD), flow-through dissolution apparatus, USP apparatus 4, hydrodynamics, natural convectionSubject (TCD):
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