Browsing School of Medicine by Title
Now showing items 242-261 of 1176
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“Dancing with Atoms”: A tribute to Sheila Tinney
(2023)The authors present a short dynamic visualization titled “Dancing with Atoms”, produced in honor of the late Irish mathematical physicist Sheila Tinney (1918--2010), the first Irish-born and -raised woman to receive a ... -
Data linkage in medical science using the resource description framework: the AVERT model
(2018)There is an ongoing challenge as to how best manage and understand ‘big data’ in precision medicine settings. This paper describes the potential for a Linked Data approach, using a Resource Description Framework (RDF) ... -
Decreased Mitochondrial DNA Mutagenesis in Human Colorectal Cancer
(2012)Genome instability is regarded as a hallmark of cancer. Human tumors frequently carry clonally expanded mutations in their mitochondrial DNA (mtDNA), some of which may drive cancer progression and metastasis. The high ... -
Defining inherited haematological disease within the Irish traveller population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2006)The Traveller Community in Ireland constitutes a minority of nomadic or semi-nomadic people, sharing a common Irish ancestry. The Traveller Health Study showed that in 1987, Travellers were only reaching the life expectancy ... -
Defining the mechanism of protection of the class 1 Allele HLA-A *03 in a single source outbreak of Hepatitis C Virus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Hepatitis C virus infects approximately 180 million persons worldwide and results in serious liver disease. Significant obstacles have hindered efforts to design an effective vaccine; in particular these include the profound ... -
Defining the mechanisms through which von willebrand factor sialic acid expression regulates in vivo clearance
(Trinity College Dublin. School of Medicine. Discipline of Haematology, 2019)Von Willebrand Factor (VWF) is a complex plasma sialoglycoprotein which plays a key role in maintaining normal haemostasis. While the biosynthesis, structure, and functions of VWF are well characterised, the molecular ... -
Defining the roles of von Willebrand Factor and Factor V111 glycosylation in regulating lectin interaction and modulating in vivo clearance
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2015)von Willebrand Factor (VWF) is a large multimeric sialoglycoprotein which mediates critical roles in normal haemostasis. VWF tethers platelets at sites of vascular injury and also serves as a chaperone for coagulation ... -
Delayed prescribing of antibiotics for respiratory tract infections: Use of information leaflets
(2013)The appropriate prescribing of antibiotics is a challenge in primary care. We performed an interventional trial to determine if providing an information leaflet on antibiotics with a delayed antibiotic prescription influenced ... -
Delaying and reversing frailty: a systematic review of primary care interventions
(2019)Background: Recommendations for routine frailty screening in general practice are increasing as frailty prevalence grows. In England, frailty identification became a contractual requirement in 2017. However, there is little ... -
Dementia - a geriatric syndrome
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Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment.
(2012)we demonstrated that dendritic cell (DC) inhibition by tumor-conditioned media in the presence or absence of bevacizumab correlates with colorectal cancer patient survival. Monitoring the influence of the tumor ... -
Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing
(2020)Bleeding and altered iron distribution occur in multiple gastrointestinal diseases, but theimportance and regulation of these changes remain unclear. We found that hepcidin, themaster regulator of systemic iron homeostasis, ... -
The Depression Network (DeNT) Study: Methodology and Sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetics study
(BMC, 2004)Background: The Depression Network Study (DeNt) is a multicentre study designed to identify genes and/or loci linked to and/or associated with susceptibility to unipolar depression in Caucasian families. This study ... -
Derivation of two iPSC lines from a sporadic ASD patient (NUIGi033-A) and a paternal control (NUIGi034-A)
(2020)Hundreds of rare risk factors have been identified for ASD, however, the underlying causes for ~70% of sporadic cases are unknown. Sporadic ASD models are thus essential for validating phenotypic commonality and drug ...