Browsing School of Medicine by Title
Now showing items 324-343 of 3153
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Blood Pressure Signal Entropy as a Novel Marker of Physical Frailty: Results from the FRAILMatics Clinical Cohort
(2022)In this study we investigated the association between information entropy in short length blood pressure signals and physical frailty status, in a group of patients aged 50+ recruited from the Falls and Syncope Unit at ... -
Body fat distribution in Turner syndrome and the influence of puberty.
(2014)Girls with Turner syndrome (TS) may encounter a wide range of problems. We aim to describe the body composition and its relation to the pubertal development, in affected girls. Precocious pubarche has been found to be ... -
"Body on the line": experiences of tackle injury in women s rugby union a grounded theory study
(2023)Objectives Tackle-related injuries account for up to 67% of all match injuries in women’s rugby union. The perspective of women players on tackle injury can help key stakeholders understand psychosocial determinants of ... -
Bone Marrow-Derived Macrophages from AβPP/PS1 Mice are Sensitized to the Effects of Inflammatory Stimuli.
(2015)Macrophages are key cells in tissue defense in the periphery and, under certain circumstances, infiltrate the central nervous system, where they may play a similar role in the brain, perhaps supporting the function of ... -
Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli
(2015)Background Lipopolysaccharide (LPS) and interferon-γ (IFNγ) increase expression of tumour necrosis factor-α (TNFα) that characterizes the M1 activation state of macrophages. Whereas it is accepted that the immune system ... -
Bordering on crisis: A qualitative analysis of focus group, social media, and news media perspectives on the Republic of Ireland-Northern Ireland border during the ?first wave? of the COVID-19 pandemic
(2021)Rationale International border controls were among the earliest and most effective of measures to constrain transmission of COVID-19. However, such measures are complex when established borders are open yet politically ... -
Brain Aβ load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD
(2019)Introduction: Successful development of effective β-site amyloid precursor protein cleaving enzyme 1 (BACE1)–targeted therapies for early stages of Alzheimer's disease requires biomarker-guided intervention strategies ... -
Brain Health in Retired Professional Rugby Union Players with a History of Concussion/Head Impact Exposure
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2021)Rugby has one of the highest incidences of concussion among all full-contact sports. There has been a global increase in rugby participation, now estimated at over eight million people worldwide. With the introduction of ... -
Brain structure, function and connectivity in Autism Spectrum Disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)In this study, two neuroimaging modalities were used to investigate neural connectivity in individuals with autism spectrum disorder; functional magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). -
Brain vs Behavior: An Effect Size Comparison of Neuroimaging and Cognitive Studies of Genetic Risk for Schizophrenia.
(2013)Genetic variants associated with increased risk for schizophrenia (SZ) are hypothesized to be more penetrant at the level of brain structure and function than at the level of behavior. However, to date the relative sensitivity ... -
BRAIN: Brain Injury in Neonates
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)Despite advances in neonatal care leading to a dramatic reduction in mortality rates in recent decades, there have been comparatively modest improvements in neurodevelopmental outcomes for infants born with neonatal ... -
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
(2013)Mutations in BRCA1/2 increase the risk of developing breast and ovarian cancer. Germline BRCA1/2 mutations occur in 8.6-13.7% of unselected epithelial ovarian cancers, somatic mutations are also frequent. BRCA1/2 mutated ... -
BRCA1/2 mutation analysis in 43 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation
(2012)Introduction: Germline mutations in DNA repair genes BRCA1/2 increase the risk of developing breast and ovarian cancer. Germline BRCA1/2 mutations occur in 8.6-13.7% of unselected epithelial ovarian cancers, somatic mutations ... -
Breast cancer detection among Irish BRCA1 & BRCA2 mutation carriers: a population-based study
(2015)Aims We investigated the presentation and screening patterns of an Irish cohort of BRCA1/2 mutation carriers with breast cancer. Materials and methods BRCA1/2 mutation carriers with breast cancer were identified in ... -
Breastfeeding and risk of overweight and obesity at nine years of age
(2012)Whether breastfeeding is protective against the development of childhood overweight and obesity remains the subject of considerable debate. Although a number of meta-analyses and syntheses of the literature have concluded ... -
Brief interventions are effective in reducing alcohol consumption in opiate dependent methadone maintained patients: results from an implementation study.
(2012)NTRODUCTION AND AIMS: An implementation study to test the feasibility and effectiveness of brief interventions (BIs) to reduce hazardous and harmful alcohol consumption in opiate-dependent methadone-maintained ... -
Btk regulates macrophage polarization in response to lipopolysaccharide.
(2014)Bacterial Lipopolysaccharide (LPS) is a strong inducer of inflammation and does so by inducing polarization of macrophages to the classic inflammatory M1 population. Given the role of Btk as a critical signal transducer ... -
Building a supportive framework for brain research in Ireland: Inaugural position paper of the Irish Brain Council
(Wiley, 2019)The Irish Brain Council is an independent group of organisations which have come together to influence and impact upon brain research in Ireland. The purpose of the Irish Brain Council is to promote ... -
Building resilience and reversing frailty: a randomised controlled trial of a primary care intervention for older adults
(2023)Background: There is a need for effective primary care interventions that help older people combat frailty and build resilience. Objective: To study the effectiveness of an optimised exercise and dietary protein ...