Browsing School of Medicine by Title
Now showing items 257-276 of 3153
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Asymmetric-flow field-flow fractionation for measuring particle size, drug loading and (in)stability of nanopharmaceuticals. The joint view of European Union Nanomedicine Characterization Laboratory and National Cancer Institute - Nanotechnology Characterization Laboratory
(2021)Asymmetric-flow field-flow fractionation (AF4) has been recognized as an invaluable tool for the characterisation of particle size, polydispersity, drug loading and stability of nanopharmaceuticals. However, the application ... -
Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain
(2011)Abstract: Background: Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial ... -
Attention Deficit Hyperactivity Disorder (ADHD) and 5-HT2C receptor: A slight increase in the transmission of Cys23 to ADHD cases
(1999)Recent evidence suggests that interaction with and balancebetween serotonergicand dopaminergic neurotransmissionis important in the mediation of hyperactive behaviour.Animal model studies have ®rmly implicated the genes ... -
Attenuated CSF-1R signalling drives cerebrovascular pathology
(2021)Cerebrovascular pathologies occur in up to 80% of cases of Alzheimer's disease; however, the underlying mechanisms that lead to perivascular pathology and accompanying blood–brain barrier (BBB) disruption are still not ... -
Attitudes of parents and staff towards medical students on the paediatric wards.
(2014)This study investigates attitudes of parents and staff to medical students on paediatric wards in a Dublin teaching hospital. We invited 100 parents of patients and 30 staff involved in the care of children on the paediatric ... -
Attitudes of women from five European countries regarding tobacco control policies.
(2013)Background: Tobacco related cancers and, in particular, lung cancer still represent a substantial public health epidemic across Europe as a result of high rates of smoking prevalence. Countries in Europe have proposed ... -
Atypical Alstrom syndrome with novel ALMS1 mutations precluded by current diagnostic criteria
(2014)We report on clinical and genetic studies in a non-consanguineous Irish sib-pair with infantile dilated cardiomyopathy and retinopathy. A diagnosis of Alström Syndrome (AS) was considered and diagnostic testing pursued. ... -
An audit of the cervical screening programme in the National Drug Treatment Centre (NDTC)
(2021)Background: Women diagnosed with substance use disorders (SUDs) have higher rates of major medical conditions compared to women without SUDs. Cervical cancer is the second leading cause of cancer death in women aged 20-39 ... -
The autism brain imaging data exchange: Towards a large-scale evaluation of the intrinsic brain architecture in autism
(2014)Autism spectrum disorders (ASDs) represent a formidable challenge for psychiatry and neuroscience because of their high prevalence, lifelong nature, complexity and substantial heterogeneity. Facing these obstacles requires ... -
Autism spectrum disorder genomics: The progress and potential of genomic technologies
(2020)Genomic technologies have accelerated research progress in autism spectrum disorder (ASD) genomics and promises to further transform our understanding of the genetic basis of this neurodevelopmental disorder. Here we review ... -
Autistic Tendencies: The Consequences for Our Culture
(2006)Professor Michael Fitzgeraldtalks withJoe Griffinabout the powerful impact, both positive and negative, of autistic thinking in diverse walks of life. -
Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease
(2010)Subjects with mild cognitive impairment (MCI) have an increased risk to develop Alzheimer?s disease (AD). Voxel-based MRI studies have demonstrated that widely distributed cortical and subcortical brain areas show atrophic ... -
Autonomic dysfunction in patients with advanced cancer; prevalence, clinical correlates and challenges in assessment.
(2012)Background: The results of a small number of studies of autonomic function in patients with advanced cancer suggest that autonomic dysfunction (AD) is common. In other disease-specific groups this is associated with decreased ... -
Autonomic function and depression in older adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2013)The principle aims of this doctoral investigation were to provide new insights into the relationship between depression and cardiovascular disease (CVD) by investigating the functioning of the autonomic nervous system (ANS) ... -
Autonomic influences on cognitive impairment : determinants of conversion to dementia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2012)Neuropathological, neurochemical and multimodal neuroimaging studies suggest that components of the central autonomic network are affected by the neurodegenerative changes of Alzheimer’s pathology in Mild Cognitive Impairment ... -
Autonomic influences on cognitive performance at a population level
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2014)The principle aims of this doctoral investigation were to provide new insights into the relationship between cardiovascular disease (CVD) and cognitive performance, by investigating the function of the autonomic nervous ...