Browsing School of Medicine by Title
Now showing items 21-40 of 3129
-
A cluster randomised trial of educational interventions to promote rational prescribing in primary care
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)A randomised controlled trial (RCT) was used to evaluate the effectiveness of individualised GP prescribing feedback delivered as a postal bulletin (PB, n=50 practices) compared to PB plus academic detailing visits (AD, ... -
A genome-wide association study for genetic susceptibility to Mycobacterium bovis infection in dairy cattle identifies a susceptibility QTL on chromosome 23
(2016)Background: Bovine tuberculosis (bTB) infection in cattle is a significant economic concern in many countries, with annual costs to the UK and Irish governments of approximately �190 million and �63 million, respectively, ... -
A molecular genetic investigation of schizophrenia in an Irish study population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2006)Schizophrenia (OMIM 181500) is a complex genetic disorder, which affects ~1% of the population, and typically presents in early adulthood with abnormalities of perception (psychosis), cognition, information processing and ... -
A novel inflammatory mediator in sinus disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Rhinosinusitis is one of the three most common disorders presenting to primary care physicians, generating high socioeconomic costs (Moss and Parsons 1986; Poole 1999). Understanding the pathomechanisms of inflammation, ... -
A novel protein NFKBIL-1 regulates the activity of key transcription factors
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Inflammation is a physiological process initiated in response to an injury or infection. Proper execution of the inflammatory response requires activation of several pro- inflammatory transcription factors. Nuclear Factor ... -
A promising hypoxia-inducible suicide gene therapy strategy for prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Gene therapy targeted to hypoxic tumour cells may allow selective killing of malignant cells. The induction of gene expression under hypoxic conditions is governed by the activation of hypoxia-inducible factor 1 and its ... -
A radomised controlled trial evaluating family mediated excercise (fame) therapy following stroke
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Physiotherapy, 2010)The aim of this study was to examine the impact of additional family mediated exercise (FAME) therapy on outcome of the lower limb (LL) following acute stroke through the implementation of a randomised controlled trial ... -
A randomised clinical trial of inpatient versus outpatient care for patients with rheumatoid arthritis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Physiotherapy, 2004)The aim of this study was to evaluate the difference in effectiveness of inpatient and outpatient rehabilitation for patients with rheumatoid arthritis from a clinical and economic perspective. Inpatient rehabilitation was ... -
A role for amyloid-β in Alzheimer's pathology : evidence from cellular, animal and pre-clinical studies
(Trinity College (Dublin, Ireland). Department of Physiology, 2012)One of the well-documented histopathological features of Alzheimer’s disease (AD) is the progressive accumulation of amyloid-β (Aβ) within the brain, thought to result from inefficient clearance of Aβ by phagocytes and/or ... -
A role for IL-1B in oxidative stress-mediated neuronal impairment
(Trinity College (Dublin, Ireland). Department of Physiology, 2000)The aims of this study were to; (1) investigate age-related changes in the antioxidant defence system in the rat cortex and hippocampus; (2) investigate the role of IL-1β in influencing oxidative stress in brain tissue of ... -
A role for interleukin-1β in synaptic function
(Trinity College (Dublin, Ireland). Department of Physiology, 2001)The proinflammatory cytokine, interleukin-1β (IL -1β ). one of the most extensively studied cytokines to date, is known to play a pivotal role in neurodegenerative, inflammatory and infectious diseases. Moreover, IL-1β ... -
A role for proteases and transcriptional regulation in the expression of ClfB on the surface of staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2002)Staphylococcus aureus is an important human pathogen. This bacterium expresses proteins on its surface capable of binding to many host ligands including fibrinogen, fibronectin, collagen, elastin and von Willebrand factor. ... -
A study of antioxidant protection in fluoride induced rat kidney lysosomal damage
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2005)Fluoride as an inorganic chemical species is ubiquitous in our environment. Fluorosis is a disease or state of chronic poisoning from long-term exposure to excessive quantities of inorganic compounds of fluorine and is a ... -
A study of food consumption patterns of children and adults in Ireland : implications for the development of food-based dietary guidelines
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Food-based dietary guidelines (FBDG) are guidelines derived from nutrient targets which are translated into food-based guidelines so they can be adopted by the general population. In order for FBDG to be successful, they ... -
A study of neuroinflammation in a mouse model of Alzheimer's disease
(Trinity College (Dublin, Ireland). Department of Physiology, 2010)Microglia are the principal immune-competent cell of the central nervous system (CNS) and there is evidence to suggest microglia are the co-ordinating cells of the CNS inflammatory response. The blood brain barrier (BBB) ... -
A study of postprandial lipoprotein metabolism and glycaemic control in a population with type 2 diabetes mellitus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Postprandial hypertriglyceridaemia predicts cardiovascular disease and is a characteristic of both obesity and poorly controlled diabetes. To address the relative impact of improved glycaemic control and weight loss on ... -
A study of the impact of highly active antiretroviral therapy on the pharmacoepidemiology and pharmacoeconomics of HIV infection
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2001)The HIV pandemic has resulted in the most intense and as yet unparalleled effort devoted to antimicrobial drug development ever to be initiated in the developed world. The intensive drug research and development, compressed ... -
A study of the potential of adult mesenchymal stem cells in bone and cartilage tissue engineering
(Trinity College (Dublin, Ireland). Department of Physiology, 2006)Adult mesenchymal stem cells (MSCs) have the potential to self-renew and differentiate into bone, cartilage, fat and muscle cells. This cell population offers significant potential for engineering of musculoskeletal tissue. ... -
A study of the role of neurotrophins in the mechanisms underlying the expression of long-term potentiation in the dentate gyrus
(Trinity College (Dublin, Ireland). Department of Physiology, 2002)Long-term potentiation (LTP) is a well-described form of synaptic plasticity. This study set out to investigate the role that tyrosine kinase plays in the expression of LTP at the perforant path-granule cell synapses of ... -
A study of transsynaptic signalling in the hippocampus : a role for nerve growth factor?
(Trinity College (Dublin, Ireland). Department of Physiology, 2001)Long-term potentiation (LTP) is perhaps the best described form of synaptic plasticity. This project aimed to investigate the role that tyrosine kinases play in the expression of LTP in dentate gyrus-granule cell synapses ...