Browsing School of Medicine by Title
Now showing items 1723-1742 of 3152
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Investigation of the link between obesity and breast cancer - the role of adipose tissue in the development and propagation of malignancy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Obesity and the metabolic syndrome are emerging risk factors for breast cancer. They are associated with increased incidence, an increased recurrence rate and a poorer prognosis. Despite this epidemiological evidence to ... -
Investigation of the molecular mechanisms underlying radioresistance in oesophageal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)The current standard of care for oesophageal cancer in Ireland involves neoadjuvant chemoradiation therapy (CRT) followed by surgery. Despite advances in treatment, resistance to neoadjuvant CRT remains a significant ... -
Investigation of the Molluscum Contagiosum Virus Protein MC089 as a Novel Inhibitor of Interferon Regulatory Factor 3 Activation
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2024)Molluscum contagiosum virus (MCV) is a human-specific poxvirus that causes highly common, mild, papular skin lesions. The lesions are notable for exerting minimal to no inflammation but can persist for a long duration ... -
Investigation of the monogenic causes of chronic kidney disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Chronic Kidney Disease (CKD) is a common chronic condition that affects 15 percent of adults in the Irish healthcare system. End stage kidney disease (ESKD) represents the final stage of CKD which culminates in the need ... -
Investigation of the pathogenicity of Rubella virus for the central nervous system
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2002)Rubella virus (RV) is the cause of a mild self limiting disease, known as German measles, which predominates during childhood. It is however the devastating teratogenic effects of this virus that are of most concern. Rare ... -
Investigation of the phenotypes, functions and therapeutic potential of expanded human invariant natural killer T cell subsets
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Invariant natural killer T (iNKT) cells comprise a rare subset of T cells that recognise glycolipid antigens presented by CDld. Activation of iNKT cells in mice leads to protection against cancer, autoimmune disease and ... -
An investigation of the role of antenatal depression, maternal cortisol and postnatal interactive behaviour on infant neurodevelopment in the first year of life.
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2019)Abstract Aims: Major Depressive Disorder (MDD) is the most prevalent psychiatric disorder during the perinatal period and can lasting adverse effects on maternal wellbeing and infant development. This aim of this thesis ... -
Investigation of the role of immunomodulators oftoll-like receptor 3 (TLR3) function and associated genetic variants in the pathogenesis and progression of idiopathic pulmonary fibrosis (IPF)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)IPF is a fatal interstitial lung disease of unknown aetiology, with a lack of valid biomarkers and satisfactory therapeutic solutions available. Studies have shown an association between inflammation, viral and bacterial ... -
Investigation of the role of RACKI in T lymphocyte migration
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Induction of the innmune response and production of pro-inflammatory cytokines results in the upregulation of ICAM-1 expressed on endothelial cells. Binding of ICAM-1 to the β2 integrin receptor LFA-1 on T cells induces T ... -
Investigation of the role of sleep and physical activity risk for chronic disease prevalence in older Irish adults
(2022)Background: Chronic diseases are the leading cause of death worldwide. Many of these diseases have modifiable risk factors, including physical activity and sleep, and may be preventable. This study investigated independent ... -
Investigation of the role of the complement system in the radioresistance of rectal cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Colorectal cancer (CRC) is the third most common cancer globally, accounting for approximately 10% of all cancer diagnoses. A third of CRCs occur in the rectum. The majority of CRCs are diagnosed at advanced stages and ... -
Investigation of α-tubulins as translational biomarkers of major depressive disorder: indications for disease severity and treatment efficacy
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Introduction: Major Depressive Disorder is a significant cause of disability worldwide. In a 2017 report, the World Health Organisation estimated that 320 million people suffered from depression globally. Although several ... -
Investigations into Pyrrolo-1,5-Benzoxazepine-15-induced apoptosis of chronic B-cell malignancies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2009)Multiple myeloma and chronic lymphocytic leukaemia (CLL) are chronic B-cell malignancies, which are characterised by the accumulation of malignant cells with low proliferative capacity and defective apoptotic mechanisms. ... -
Investigations into the role of mast cell mediated effects on the intestinal epithelial barrier in vitro : implications for the pathogenesis of irritable bowel syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)Irritable bowel syndrome (IBS) is a highly prevalent functional bowel disorder characterised by abdominal pain or discomfort and associated with altered bowel habit, abdominal bloating and disturbed defecation. The aetiology ... -
Investigations of Aspergillus infection in Cystic Fibrosis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2015)Aspergillus fumigatus is a ubiquitous saprophytic fungus that is a pathogen in principally immunocompromised hosts. It is the most common fungal pathogen in Cystic Fibrosis (CF), most often associated with Allergic ... -
Involving older people in co-designing a primary-care intervention to reverse frailty and build resilience
(2021)Background: An essential consideration in health research is to conduct research with members of the public rather than for them. Public and patient involvement (PPI) of older people in research can improve enrolment, ... -
The Irish health system and the crisis: a case study in the struggle for the capacity of the Social State
(2018)Ireland’s health care system is a weak Beveridgean system with no entitlement to free care and substantial acute waiting lists. Just under half the population has voluntary private health insurance and there is a two-tier ... -
Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice.
(2019)Among the changes that typify Alzheimer’s disease (AD) are neuroinflammation and microglial activation, amyloid deposition perhaps resulting from compromised microglial function and iron accumulation. Data from Genome Wide ...