A high-density ERP study reveals latency, amplitude, and topographical differences in multiple sclerosis patients versus controls.
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2010Citation:
Whelan R, Lonergan R, Kiiski H, Nolan H, Kinsella K, Bramham J, O'Brien M, Reilly RB, Hutchinson M, Tubridy N, A high-density ERP study reveals latency, amplitude, and topographical differences in multiple sclerosis patients versus controls., Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 121, 9, 2010, 1420-1426Download Item:
A high-density ERP.pdf (Published (author's copy) - Peer Reviewed) 76.37Kb
Abstract:
Objective. To quantify latency, amplitude and topographical differences in
event-related potential (ERP) components between multiple sclerosis (MS)
patients and controls and to compare ERP findings with results from the
paced auditory serial addition test (PASAT).
Methods. Fifty-four subjects (17 relapsing remitting (RRMS) patients, 16
secondary progressive (SPMS) patients, and 21 controls) completed visual
and auditory oddball tasks while data were recorded from 134 EEG channels.
Latency and amplitude differences, calculated using composite mean
amplitude measures, were tested using an ANOVA. Topographical
differences were tested using statistical parametric mapping (SPM).
Results. In the visual modality, P2, P3 amplitudes and N2 latency were
significantly different across groups. In the auditory modality, P2, N2, and P3
latencies and N1 amplitude were significantly different across groups. There
were no significant differences between RRMS and SPMS patients on any
ERP component. There were topographical differences between MS patients
and controls for both early and late components for the visual modality, but
only in the early components for the auditory modality. PASAT score
correlated significantly with auditory P3 latency for MS patients.
Conclusions. There were significant ERP differences between MS patients
and controls.
Significance. The present study indicated that both early sensory and later
cognitive ERP components are impaired in MS patients relative to controls.
Sponsor
Grant Number
Enterprise Ireland
Author's Homepage:
http://people.tcd.ie/reillyrihttp://people.tcd.ie/whelanr3
http://people.tcd.ie/kiiskih
http://people.tcd.ie/nolanh4
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PUBLISHEDType of material:
Journal ArticleSeries/Report no:
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology121
9
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Full text availableKeywords:
Neuroscience, Multiple sclerosisSubject (TCD):
Neuroscience , Next Generation Medical DevicesDOI:
http://dx.doi.org/10.1016/j.clinph.2010.03.019ISSN:
1388-2457Licences: