Browsing by Author "WHELAN, ROBERT"
Now showing items 1-18 of 18
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Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior
BOKDE, ARUN; WHELAN, ROBERT (2017)Background Individual differences in impulsivity and early adversity are known to be strong predictors of adolescent antisocial behavior. However, the neurobiological bases of impulsivity and their relation to antisocial ... -
Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat
BOKDE, ARUN; WHELAN, ROBERT (2015)Cannabis use in adolescence may be characterized by differences in the neural basis of affective processing. In this study, we used an fMRI affective face processing task to compare a large group (n = 70) of 14-year olds ... -
Decreased frontal, striatal and cerebellar activation in adults with ADHD during an adaptive delay discounting task
WHELAN, ROBERT; GARAVAN, HUGH; O'CONNELL, REDMOND (2015)An important characteristic of childhood attention-deficit/hyperactivity disorder (ADHD) is a bias towards small immediate versus larger delayed rewards, but it is not known if this symptom is also a feature of adult ADHD. ... -
Delayed P100-Like Latencies in Multiple Sclerosis: A Preliminary Investigation Using Visual Evoked Spread Spectrum Analysis.
REILLY, RICHARD; WHELAN, ROBERT; LALOR, EDMUND (2016)Conduction along the optic nerve is often slowed in multiple sclerosis (MS). This is typically assessed by measuring the latency of the P100 component of the Visual Evoked Potential (VEP) using electroencephalography. The ... -
Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
WHELAN, ROBERT; GILL, MICHAEL; CORVIN, AIDEN; BOKDE, ARUN; DONOHOE, GARY (2016)The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still ... -
Identifying disordered eating behaviours in adolescents: how do parent and adolescent reports differ by sex and age?
WHELAN, ROBERT; BOKDE, ARUN; Bartholdy, Savani; Allen, Karina; Hodsoll, John; O'Daly, Owen G.; Campbell, Iain C.; Banaschewski, Tobias; Bromberg, Uli; Büchel, Christian; Burke Quinlan, Erin; Conrod, Patricia J.; Desrivieres, Sylvane; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Artiges, Eric; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Paus, Tomáš; Poustka, Luise; Smolka, Michael N.; Mennigen, Eva; Walter, Henrik; Schumann, Gunter; Schmidt, Ulrike (2017)This study investigated the prevalence of disordered eating cognitions and behaviours across mid-adolescence in a large European sample, and explored the extent to which prevalence ratings were affected by informant ... -
Inferred Threat and Safety: Symbolic Generalization of Human Avoidance Learning
WHELAN, ROBERT (2011)Symbolic generalization of avoidance may underlie the etiology and maintenance of anxiety disorders. The aim of the present study was to demonstrate inferred threat-avoidance and safety (non-avoidance) behaviours that occur ... -
Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents.
BOKDE, ARUN; WHELAN, ROBERT (2017) -
Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology
BOKDE, ARUN; KELLY, CLARE; RUDDY, KATHY; WHELAN, ROBERT; O'Halloran, Laura; Cao, Zhipeng; Jollans, Lee; Albaugh, Matthew D.; Aleni, Andrea; Potter, Alexandra S.; Vahey, Nigel; Banaschewski, Tobias; Hohmann, Sarah; Bromberg, Uli; Büchel, Christian; Burke Quinlan, Erin; Desrivieres, Sylvane; Flor, Herta; Frouin, Vincent; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Paus, Tomáš; Smolka, Michael N.; Walter, Henrik; Schumann, Gunter; Garavan, Hugh (2017)Moment-to-moment reaction time variability on tasks of attention, often quantified by intra-individual response variability (IRV), provides a good indication of the degree to which an individual is vulnerable to lapses in ... -
Neuromarkers for mental disorders: Harnessing population neuroscience
WHELAN, ROBERT (2018) -
Neuropsychosocial profiles of current and future adolescent alcohol misusers.
BOKDE, ARUN; WHELAN, ROBERT (2014)A comprehensive account of the causes of alcohol misuse must accommodate individual differences in biology, psychology and environment, and must disentangle cause and effect. Animal models can demonstrate the effects of ... -
A phenotypic structure and neural correlates of compulsive behaviors in adolescents.
GARAVAN, HUGH; WHELAN, ROBERT (2013)BACKGROUND: A compulsivity spectrum has been hypothesized to exist across Obsessive-Compulsive disorder (OCD), Eating Disorders (ED), substance abuse (SA) and binge-drinking (BD). The objective was to examine the validity ... -
Sex differences in COMT polymorphism effects on prefrontal inhibitory control in adolescence.
BOKDE, ARUN; WHELAN, ROBERT (2014)Catecholamine-0-methyl-transferase (COMT) gene variation effects on prefrontal blood oxygenation-level-dependent (BOLD) activation are robust; however, despite observations that COMT is estrogenically catabolized, sex ... -
Very large fMRI study using the IMAGEN database: sensitivity - specificity and population effect modelling in relation to the underlying anatomy
WHELAN, ROBERT (2012)In this paper we investigate the use of classical fMRI Random Effect (RFX) group statistics when analysing a very large cohort and the possible improvement brought from anatomical information. Using 1326 subjects from the ...