Physiology: Recent submissions
Now showing items 1-20 of 237
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Investigating the therapeutic utility of Olaparib in Metachromatic Leukodystrophy and Krabbe Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2024)Leukodystrophies encompass a diverse group of genetically-based disorders that impact the development and preservation of myelin in the central nervous system's white matter. These conditions, affecting approximately 1 in ... -
The Impact and Influence of Sports Related Concussion and Cardiovascular Risk Factors on Brain and Heart Health across an Ageing Population
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)This study focused on the relationship between perceptual performance, brain health, and cardiovascular (CV) profiles in both recreational athletes and non-athletes, bridging the gap between sensory integration, cognitive ... -
Identifying the therapeutic potential of novel compounds in the treatment of Glioblastoma Multiforme
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer in adults with a dismal 5-year survival rate of <5%. Despite advanced diagnostic and multimodal treatments including surgery, followed by ... -
Low-volume HIIT and MICT speed VO2 kinetics during high-intensity "work-to-work" cycling with a similar time-course in type 2 diabetes
(2022)We assessed the rates of adjustment in oxygen uptake (V̇o2) and muscle deoxygenation [i.e., deoxygenated hemoglobin and myoglobin, (HHb + Mb)] during the on-transition to high-intensity cycling initiated from an elevated ... -
Priming exercise accelerates oxygen uptake kinetics during high-intensity cycle exercise in middle-aged individuals with type 2 diabetes
(2022)Background: The primary phase time constant of pulmonary oxygen uptake kinetics ( ⋅VO2 τ p) during submaximal efforts is longer in middle-aged people with type 2 diabetes (T2D), partly due to limitations in oxygen supply ... -
Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine
(2022)One area of microglial biology that has been relatively neglected until recently is sex differences and this is in spite of the fact that sex is a risk factor in several diseases that are characterized by neuroinflammation ... -
Effects on an acute priming exercise and high-intensity interval training on oxygen uptake and muscle deoxygenation kinetics in older individuals with type 2 diabetes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2021)Peak oxygen uptake (V̇O2peak) is consistently reduced in individuals with type 2 diabetes (T2D) of all ages compared with non-diabetic (ND) controls. In middle-aged (between 45 to 60 y) individuals with T2D these reductions ... -
Elucidating the complex organization of neural micro-domains in the locust Schistocerca gregaria using dMRI
(2021)To understand brain function it is necessary to characterize both the underlying structural connectivity between neurons and the physiological integrity of these connections. Previous research exploring insect brain ... -
From Mechanisms to Analgesia: Towards the Use of Non-Invasive Neuromodulation for Pain Relief in the Clinic
(Intech Open, 2020)The use of electricity for analgesic effects has a long history and yet currently neuromodulation devices based on electrical stimulation are typically restricted to being a last resort intervention for pain patients after ... -
Influence of type 2 diabetes on muscle deoxygenation during ramp incremental cycle exercise
(2019)We tested the hypothesis that type 2 diabetes (T2D) alters the profile of muscle fractional oxygen (O2) extraction (near-infrared spectroscopy) during incremental cycle exercise. Seventeen middle-aged individuals with ... -
Priming exercise accelerates pulmonary oxygen uptake kinetics during "work-to-work" cycle exercise in middle-aged individuals with type 2 diabetes
(2021)Purpose: The time constant of phase II pulmonary oxygen uptake kinetics ([Formula: see text]) is increased when high-intensity exercise is initiated from an elevated baseline (work-to-work). A high-intensity priming exercise ... -
A 2.5min cold water immersion improves prolonged intermittent sprint performance
(2019)Objectives: We investigated if cold water immersion (CWI) affects exercise performance during a prolonged intermittent sprint test (IST), designed to mimic activity patterns of team-sports. Design: Randomized-crossover ... -
Effect of low recumbent angle on cycling performance, fatigue and VO2 kinetics.
(2013)Purpose: This study aimed to examine the effect of the degree of inclination from upright to supine postures on cycling performance, fatigue, and oxygen uptake (V˙O(2)) kinetics. Methods: In experiment 1, 10 subjects ... -
Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid
(2018)Background: Microglia are multifunctional cells that are primarily neuroprotective and a deficit in their functional integrity is likely to be a contributory factor in the deteriorating neuronal function that occurs with ...