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  Targeting the noradrenergic system for anti-inflammatory and neuroprotective actions in an animal model of Parkinson's disease 

  Yssel, Justin David (Trinity College (Dublin, Ireland). Department of Physiology, 2015)

  Parkinson's disease (PD) is a common neurodegenerative disorder that is characterised by the selective loss of dopamine (DA) neurons within the substantia nigra pars compacta and results in reduced striatal DA input ...
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  The role of S1P receptors and their interacting proteins in Krabbe Disease 

  O'Sullivan, Catherine (Trinity College (Dublin, Ireland). Department of Physiology, 2015)

  Globoid cell leukodystrophy (Krabbe disease, KD) is a rare autosomal recessive neurodegenerative disorder that presents within the first six months of life and is usually fatal by the age of two years. KD is caused by a ...
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  The effect of excercise and pioglitazone on the dynamic responses of oxygen uptake and leg vascular conductance in males with type 2 diabetes 

  O'Connor, Eamonn (Trinity College (Dublin, Ireland). Department of Physiology, 2012)

  The exercise capacity of an individual with T2D is often reduced due to the effects of T2D upon oxygen consumption- (VO2) and vascular conductance (VC)- kinetics. Exercise training has been shown to induce improvements in ...
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  Evaluation of novel biomarkers in the detection of chemotherapy-mediated cardiac and kidney injury 

  Jones, Melissa (Trinity College (Dublin, Ireland). Department of Physiology, 2015)

  Chemotherapeutic agents are associated with a risk for potential cardiac and kidney injury, however diagnostic techniques currently used to assess cardiac function lack sensitivity, whilst those used to evaluate kidney ...
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  The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages 

  Lynch, Marina; Finucane, Orla; Sugrue, Jamie; Rubio-Araiz, Ana; Guillot-Sestier, Marie-Victoire (2019)

  Infammation and metabolism are intricately linked during infammatory diseases in which activation of the nucleotide-binding domain–like receptors Family Pyrin Domain Containing 3 (NLRP3) infammasome, an innate immune ...

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