RSS 1.0Physiology
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Physiology (Scholarly Publications)
Physiology (Scholarly Publications)
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Age-associated dysregulation of microglial activation is coupled with enhanced BBB permeability and pathology in APP/PS1 mice
(2014)Aging adversely affects inflammatory processes in the brain, which has important implications in the context of disease progression. It has been proposed that microglia become dysfunctional with age and may lose their ... -
Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice.
(2014)Alzheimer?s disease (AD) is a progressive neurodegenerative disease characterized by deposits of amyloid-? and neurofibrillary tangles. It has been suggested that inflammatory changes are associated with disease; however, ... -
Classical activation of microglia in CD200-deficient mice is a consequence of blood brain barrier permeability and infiltration of peripheral cells.
(2013)The interaction between CD200, expressed on several cell types, and its receptor CD200R, expressed on cells of the myeloid lineage, has been shown to be an important factor in modulating inflammation in macrophage function ... -
Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased A? accumulation and microglial activation.
(2013)Background: Alzheimer?s Disease is characterized by progressive neuronal loss and cognitive decline. Epidemiological studies suggest that the risk of AD is higher in women even when data are adjusted for age. Objective: ... -
The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease.
(2013)Neuroinflammatory changes are a characteristic of several, if not all, neurodegenerative diseases including Alzheimer?s disease (AD) and are typified by increased microglial activation. Microglia express several receptors ... -
The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation.
(2012)Background: Several factors contribute to the deterioration in synaptic plasticity which accompanies age and one of these is neuroinflammation. This is characterized by increased microglial activation associated with ... -
Dok2 mediates the CD200Fc attenuation of A?-induced changes in glia.
(2012)Background: The interaction between the membrane glycoprotein, CD200 and its cognate receptor CD200 receptor (CD200R), has been shown to play a role in maintaining microglia in a quiescent state. There is evidence of ... -
LPS-induced release of IL-6 from glia modulates production of IL-1? in a JAK2-dependent manner.
(2012)Background: Compelling evidence has implicated neuroinflammation in the pathogenesis of a number of neurodegenerative conditions. Chronic activation of both astrocytes and microglia leads to excessive secretion ... -
IFN-? Production by Amyloid ?-Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease.
(2013)Alzheimer?s disease (AD) is characterized by the presence of amyloid-b (Ab)?containing plaques, neurofibrillary tangles, and neuronal loss in the brain. Inflammatory changes, typified by activated microglia, particularly ... -
The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner.
(2013)Fibroblast growth loop (FGL) is a neural cell adhesion molecule (NCAM)-mimetic peptide that mimics the interaction of NCAM with fibroblast growth factor receptor (FGFR). FGL increases neurite outgrowth and promotes ... -
Modest Amyloid Deposition is Associated with Iron Dysregulation, Microglial Activation, and Oxidative Stress.
(2012)There is a well-established literature indicating a relationship between iron in brain tissue and Alzheimer's disease (AD). More recently, it has become clear that AD is associated with neuroinflammatory and oxidative ... -
Rosiglitazone improves spatial memory and decreases insoluble A?(1-42) in APP/PS1 mice.
(2012)Identifying potential novel treatments for patients with Alzheimer?s disease (AD) is a major challenge and drugs used for other indications, particularly if they have anti- inflammatory properties, are particularly ... -
Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP.
(2012)Neuroinflammation is a significant and consistent feature of many neurodegenerative disorders, including Alzheimer?s disease (AD) and Parkinson?s disease (PD). The greatest risk factor for neurodegenerative disorders is ... -
The Age-related Gliosis and Accompanying Deficit in Spatial Learning are Unaffected by Dimebon.
(2013)A non-selective antihistamine, dimebon, has recently emerged as a potential treatment for Alzheimer's disease and Huntington's disease. Dimebon exerts several effects in addition to its anti-histaminergic effect, and of ... -
The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability.
(2012)In view of the increase in the aging population and the unavoidable parallel increase in the incidence of age-related neurodegenerative diseases, a key challenge in neuroscience is the identification of clinical signatures ... -
Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction.
(2013)Increasing global birth rate, coupled with the aging population surviving into their eighth decade has lead 26 to increased incidence diseases, hitherto designated as rare. Brain related ischemia, at birth, or later in ... -
Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β
(2013)The family of toll-like receptors (TLR) plays a major role in innate immunity due to their pathogen-recognition abilities. TLR3 is a sensor for double-stranded RNA, and regulates host-defense responses to several viruses, ... -
Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL
(2012)Altered synaptic morphology, progressive loss of synapses and glial (astrocyte and microglial) cell activation are considered as characteristic hallmarks of ageing. Recent evidence suggests that there is a concomitant ...