Browsing Genetics (Theses and Dissertations) by Subject "gene therapy"

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    • Development of gene therapies for retinal degenerations 

      Shortall, Ciara (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)
      The studies described in this thesis explore potential gene therapies for retinal degenerative diseases using adeno-associated virus (AAV) vectors for gene delivery. Inherited retinal degenerations (IRDs) are a leading ...

    • Exploration of gene therapies targeting oxidative stress and NAD+ pathways for the treatment of optic neuropathy 

      Finnegan, Laura Katharine (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)
      The World Health Organisation estimates that there are approximately 300 million people suffering from some form of blindness, from inherited retinal degenerations to complex diseases such as glaucoma. The vast heterogeneity ...