Browsing Genetics (Theses and Dissertations) by Subject "Genetics, Ph.D."
Now showing items 1-20 of 115
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A bioinformatics approach to (intra-) genome comparisons
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2002)The analysis of large volumes of genomic data generates special computational needs. A Beowulf-type computer cluster was set up for high-performance computing. Improvements over existing tools for the efficient ... -
A functional genomics approach to study plant reproductive development
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)A fundamental question in developmental biology is how differentiated cell types and organs are formed from undifferentiated precursor cells. The establishment of the body plan of an organism is ultimately defined by its ... -
A leaf-specific phage T7 RNA polymerase-based system for transgene expression in tobacco chloroplasts
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)This thesis describes the development of a chloroplast-localised gene expression system based on the phage T7 RNA polymerase. In order to direct T7 RNAP expression in a leaf-specific manner and to target it to the ... -
A molecular genetic investigation of Irish origins
(Trinity College (Dublin, Ireland). Department of Genetics, 2000)Three hundred and ninety-four male DNA samples, from Ireland, Turkey and Togo, were genotyped for 5 X chromosome simple tandem repeat (STR) loci. Six Y chromosome STR loci and 8 Y chromosome unique event polymorphisms were ... -
A study of the expression and roles of Bacillus subtilis HtrA-type serine proteases
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)Upon sequencing a region of the Bacillus subtilis genome assigned to the author of this thesis, an open reading frame encoding a homologue of an HtrA-type serine protease, YkdA, was identified. The HtrA serine protease ... -
A study of the regulation of aminoacyl tRNA synthetase gene expression in Bacillus by T-box regulatory elements
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2010)The T-box antitermination mechanism is commonly used for the regulation of aminoacyl tRNA synthetase gene expression in Gram positive bacteria. However, expression of lysyl tRNA synthetases is rarely controlled in this ... -
An examination of Serotonergic candidate genes in Attention Deficit Hyperactivity Disorder
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Attention Deficit Hyperactivity Disorder (ADHD) is a common, highly heritable childhood disorder. It is characterised by symptoms of inattention, hyperactivity, and impulsivity. Heritability of ADHD is estimated to be ... -
An investigation into the complex genetics of bipolar affective disorder : potential susceptibility loci and candidate genes from the Irish population
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Bipolar affective disorder (BPAD) is a serious and debilitating psychiatric illness characterised by extreme changes in mood, ranging from depression to mania. BPAD is undoubtedly caused by genetic factors, with some ... -
An investigation of the role of caspase-9-interacting proteins in the molecular control of apoptosis
(Trinity College (Dublin, Ireland). Department of Genetics, 2001)Apoptosis is an important homeostatic mechanism that multicellular organisms utilize to delete cells during development and on an ongoing basis in the adult. At the molecular level, this requires the activation of a family ... -
An investigation of the specificity of interaction in two-component systems using YycFG and PhoPR of Bacillus subtilis as a model system
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2009)Presented in this thesis is a study of the specificity of interaction between histidine kinases and response regulators in two-component systems using YycFG and PhoPR as model system in B. subtilis. -
Analysis of the gene regulatory network underlying reproductive floral organ development through gene perturbation experiments
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)Homeosis or homeotic transformation refers to the formation of one body structure or organ in place of another. For more than two decades, the floral homeotic genes have been at the center of intense studies that showed ... -
Automated annotation of yeast genomes
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)I have built an automated annotation pipeline (named YGAP - Yeast Genome Annotation Pipeline), designed specifically for new yeast genome sequences lacking transcriptome data. YGAP uses homology and synteny information ... -
Bovini mitochondrial DNA : demographic history and recombination
(Trinity College (Dublin, Ireland). Department of Genetics, 2006)Bovini mitochondrial sequences were analysed at levels from intra-population studies to inter-species analyses. D-loop sequences were analysed to draw conclusions about the domestication of water buffalo and the demographic ... -
Caspase and granzyme regulated events in apoptosis and inflammation
(Trinity College (Dublin, Ireland). Department of Genetics, 2011)The caspase and granzyme proteases are key regulators of both programmed cell death (apoptosis) and inflammation. They achieve this regulation through the limited proteolysis of protein substrates, this has the consequence ... -
Cell signalling and ADP ribosylation factor 1 (Arf1) effector proteins of African trypanosomes
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)The control of population size and differentiation status is essential for the survival of all organisms. Tight regulation of these processes is of particular importance for parasites. The African trypanosome, Trypanosoma ... -
Characterization of Arabidopsis homologs of the Drosophila SET domain gene Su(var)3-9
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)SET domain-containing proteins encoded by the Drosophila gene Su(var)3-9 and its human homologue, SUV39H1, are major regulators of heterochromatin formation. The SET domains of these proteins carry histone methyltransferase ... -
Characterization of two flowering gene homologues from Lolium perenne
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)Lolium perenne (perennial ryegrass) is a primary source of fodder for grazing cattle and is therefore of significant agricultural and economic importance. Understanding the flowering process in this species may help to ... -
Characterization of two genes transcribed from a divergent promotor in Arabidopsis thaliana and encoding plastid-targeted proteins
(Trinity College (Dublin, Ireland). Department of Genetics, 2001)As part of the Arabidopsis genome sequencing project, approximately 85kb of sequence data on chromosome 4 was generated in this laboratory. This included a cosmid clone called cAt4S5 containing a genomic insert of 13.3kb ... -
Cloning and functional characterisation of genes involved in cell death and cell survival
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)During development and as a result of infection or injury, individual cells of multicellular organisms are required to mount appropriate survival or death responses. Two main signalling pathways are responsible for these ... -
Comparative analysis of human and mouse acute phase Serum Amyloid A gene expression
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)The Serum Amyloid A (S AA) proteins are a family of highly conserved lipoproteins secreted by the liver. Their production and release is massively induced under conditions of inflammation or infection by pro-inflammatory ...