Browsing Genetics (Theses and Dissertations) by Sponsor "Irish Research Council (IRC)"
Now showing items 1-11 of 11
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Colony Stimulating Factor 1 Receptor and Blood-Brain Barrier Maintenance
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)Cerebrovascular pathologies occur in up to 80% of cases of Alzheimer's disease; however, the underlying mechanisms that lead to perivascular pathology and accompanying blood-brain barrier (BBB) disruption are still not ... -
Comparing Pathways for Retinal and Neuronal Degeneration in Drosophila melanogaster
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Past work to understand the mechanisms of cellular degeneration has either focused on retinal degeneration or neurodegeneration. These studies have revealed that the integrated stress response (ISR) and RNA binding proteins ... -
Exploring the functions of PRC2 in development and congenital disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)Polycomb group (PcG) proteins are key chromatin-based repressors of gene expression that play important roles in lineage-specification and cellular memory. PcG proteins assemble into multi-subunit complexes, termed Polycomb ... -
Functional assessment of non-coding regulatory variants in familial breast cancer
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2020)Breast cancer is the most common cancer in Irish women, with almost 3,000 cases diagnosed every year. It often runs in families, and some women inherit a greater risk of developing the disease. Landmark studies on these ... -
Identifying Blood-Brain Barrier Pathologies and Novel Therapeutic Targets in Epilepsy and Neuropsychiatric Disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)The blood-brain barrier (BBB) is vital for maintaining homeostasis of the neural microenvironment. Tight junctions composed of the transmembrane proteins claudin-5 and occludin contribute to the function of this barrier ... -
Interpretation and improvement of the current genetic epidemiology methodology for schizophrenia
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Recent technological advancements have allowed for the development of new methodologies in the investigation of the genetic epidemiology of schizophrenia. Two of the most prominent methods in that field are the Polygenic ... -
Investigating the molecular mechanisms that control the transformation of leaves into floral organs.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)Arabidopsis thaliana is the model plant which has been used to elucidate the molecular and genetic processes which underlie floral organogenesis. This is the process in which the four floral organs are formed which is ... -
Investigating the Role of the 3'UTR of Claudin-5 and Circadian Rhythms at Tight Junctions in the Blood-Brain Barrier
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2020)The blood-brain barrier (BBB) is comprised of the vasculature surrounding the central nervous system (CNS), and most importantly consists of endothelial cells. These brain endothelial cells have unique properties that ... -
Mechanisms of action and vulnerabilities associated with the oncogene EZH2 in germinal centre B-cell non-Hodgkin lymphoma
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)Polycomb group (PcG) proteins are highly conserved chromatin regulators that play a critical role as transcriptional repressors in mediating and maintaining cellular identity. PcG proteins assemble into large, distinct, ... -
RNP granules-dependent translational regulation in habituation and development
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Habituation is defined as a reduced behavioral response to a stimulus after repeated or continuous exposure. Long-term habituation (LTH) is a long-lasting form of non-associative memory which is dependent on de novo protein ... -
Understanding the role of accessory components in regulation of the Polycomb Repressive Complex 2 in mESCs and cancer
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)Polycomb Repressive Complex 2 is a chromatin regulatory complex composed of core subunits EZH1/2, EED, SUZ12 and RBBP4/7, around which several accessory components assemble in a mutually exclusive manner to form structurally ...