Browsing Genetics (Theses and Dissertations) by Sponsor "European Research Council (ERC)"
Now showing items 1-10 of 10
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Alternative routes to optimal expression levels: Evolutionary evidence for competitive RNAs and dosage compensation by gene duplication
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)Expression evolution and dosage constraints are important factors shaping genomic content and innovation. It has become increasingly clear that non-coding RNAs perform various regulatory functions in different cellular ... -
A characterisation of gene duplicability: its determining factors and impact on duplicate evolution
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)Duplication, either through whole genome duplication or small-scale duplication, is a critical process in evolution. The duplication of genetic material provides ample opportunity for adaptation and innovation through the ... -
Herding Ancient Domesticates: From Bones to Genomes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)This thesis demonstrates the power of the analysis of ancient domesticate genomes of cattle and sheep in order to analyse past population dynamics of the two species. In total 113 whole genomes and 127 mitogenomes of wild ... -
The Multilayered Prehistory of Wild Aurochs and Domestic Cattle
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)This thesis explores 122 ancient genomes of domestic cattle and wild aurochs to investigate past population events such as domestication and admixture. Population genomics of ancient taurine domestics from the ancient Near ... -
A novel gene-based therapy for galaucoma:from discovery to preclinical development
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Introduction: Glaucoma is a multifactorial condition that will often result in complete bilateral blindness if untreated. Elevated intraocular pressure (IOP) is both a major risk factor and indicator of disease. IOP is ... -
Novel therapeutic approaches for open-angle glaucoma
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)Glaucoma is the leading cause of blindness worldwide after cataracts and it is estimated that the global prevalence of glaucoma will increase to 111.8 million by 2040 (1, 2). Primary open-angle glaucoma (POAG) is characterized ... -
Persistent, ancient constraints shape copy number and expression variation of dosage-sensitive genes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2017) -
Primary open-angle glaucoma: on the development of novel therapeutic approaches
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Glaucoma is one of the most prevalent forms of preventable blindness, affecting more than 60 million people worldwide. While normotensive forms of the disease do exist, the majority of cases are caused by elevations in ... -
Retrieval of DNA from ancient material and the demography of the extinct aurochs
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Ancient DNA has revolutionised our understanding of animal genomics by providing direct evidence of the demography of ancient wild populations and unravelling the complex domestication process with time-stamped precision. ... -
Targeting the tight-junctions of the conventional outflow pathway in primary open-angle glaucoma.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Primary open-angle glaucoma (POAG) is one of the leading causes of blindness worldwide, affecting an estimated 44.1 million people (Tham et al. 2014). POAG is characterised by elevated intraocular pressure (IOP) due to ...