Browsing Genetics (Theses and Dissertations) by Date of Publication
Now showing items 21-40 of 195
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Molecular and quantative analyses of genetic variation in farmed Atlantic salmon
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)Genetic diversity between three farmed and four wild populations and within six 6 year classes of one farmed population of Atlantic salmon were analysed using 15 microsatellite markers. High levels of polymorphism were ... -
Genetic admixture analysis of domesticated cattle
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)Genetic admixture analysis of bovine hybrid zones was carried out through implementation of a variety of statistical and analytical methods. Population genetic analysis of microsatellite variation in seven cattle breeds ... -
The development of gene therapy techniques and animal models for Retinitis Pigmentosa and towards the identification of a novel RP-causing gene in a family of Irish origin
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)The work presented in this thesis pertains to several different stages in the preclinical development of therapeutics for inherited retinal disease. Chapter two addresses the difficult challenge of delivery of therapeutics ... -
Genetic variation in domesticated cattle and wild aurochsen using ancient and modern data
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)A total of 101 Bos taurus teeth and bones aged between 1,000 to 9,000 years old, and 45 B. primigenius primigenius bones aged between 3,720 to 12,380 years old, were assessed for the presence of verifiable mitochondrial ... -
Family-based molecular genetic studies in bipolar affective disorder
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)This thesis covers gene mapping experiments applied to bipolar affective disorder (BPD), a severe recurrent psychiatric condition with a lifetime prevalence of 1-2%, and a substantial familial component. The study sample ... -
Molecular genetic investigations of the diversity and origins of Old and New World cattle population
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)One hundred and forty-nine Bos indicus mitochondrial DNA (mtDNA) control region sequences sampled from the Indian subcontinent, the Near East and East Asia were assessed in order to investigate the domestic origins and ... -
Investigation of the YycFG two-component signal transduction system in Bacillus subtilis
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)The work in this thesis describes a novel approach to investigating the YycFG two-component signal transduction system of Bacillus subtilis. The YycFG TCSTS was found to be the only essential two-component signal transduction ... -
Evolution of the genomes of two nematodes in the genus Caenorhabditis
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)The soil-dwelling nematode Caenorhabditis elegans has been intensively studied as a model organism for the last 40 years. It was the first animal for which we had a complete description of development, anatomy, a neural ... -
Investigations on apoptosis-associated caspase activation cascades
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)Apoptosis is an important process in a wide variety of different biological systems such as the immune system, normal cell turnover and embryonic development (Stennicke et al., 2002). Apoptosis is characterized by a series ... -
The monocyte protein C pathway : implications in human diseases
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)The protein C (PC) pathway provides an important link between the coagulation, fibrinolytic, and inflammatory pathways. PC/activated protein C (APC) is one o f very few therapies shown to effectively reduce the morbidity ... -
Cloning and functional characterisation of genes involved in cell death and cell survival
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)During development and as a result of infection or injury, individual cells of multicellular organisms are required to mount appropriate survival or death responses. Two main signalling pathways are responsible for these ... -
On the molecular genetics of hereditary degenerative retinopathies
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)The central aim of this thesis was the elucidation of the underlying molecular pathologies of inherited diseases of the retina. The main focus of study concentrates on the molecular genetics and disease mechanisms in ... -
Characterization of Arabidopsis homologs of the Drosophila SET domain gene Su(var)3-9
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)SET domain-containing proteins encoded by the Drosophila gene Su(var)3-9 and its human homologue, SUV39H1, are major regulators of heterochromatin formation. The SET domains of these proteins carry histone methyltransferase ... -
Comparative genomics in yeasts
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)Comparative genomics allows us to delve into the fundamental differences among species that form the basis of biodiversity, as well as the preservative forces of natural selection that have left many things unchanged. It ... -
Genetic investigation of Irish ancestry and surname history
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)Several genetic systems were employed in this study to investigate Ireland’s pre-history and history. Initially Irish origins were examined using mtDNA sequence variation in 200 new samples coupled with an extensive novel ... -
On the molecular genetics of bipolar affective disorder
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)This thesis describes genome-wide gene mapping analyses as applied to bipolar affective disorder (BPAD). This condition is a severe recurrent psychiatric disorder, with a substantial familial component and an estimated ... -
Y chromosomes and Irish phylogeography
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)A High-Resolution Y Chromosome Survey of Ireland. In order to investigate the origins of the Irish population and to describe the population genetic events that have shaped the extant Irish gene pool, Y chromosome genetic ... -
Functional characterisation of Arabidopsis genes encoding members of the AP2/ERF transcription factor family
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)The EU Framework 5 REGIA (Regulatory Gene Initiative in Arabidopsis) Consortium, comprising 29 laboratories, was established to investigate transcription factor gene function in Arabidopsis. As part of the REGIA project, ... -
Characterization of two flowering gene homologues from Lolium perenne
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)Lolium perenne (perennial ryegrass) is a primary source of fodder for grazing cattle and is therefore of significant agricultural and economic importance. Understanding the flowering process in this species may help to ... -
Examinations of DRD4, DRD5 and SNAP-25 as candidate genes in Attention Deficit Hyperactivity Disorder
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)Attention deficit hyperactivity disorder (ADHD) is a common early onset childhood disorder. Symptoms o f the disorder include inattentiveness, impulsiveness, distractibility and hyperactivity. Family, twin and adoption ...
