Browsing Clinical Medicine (Theses and Dissertations) by Subject "M.D. Trinity College Dublin"
Now showing items 1-20 of 27
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A surgical delivery system for targeted cancer gene therapy : the potential therapeutic role of genetically modified microvascular free flaps in the management of primary tumours
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Gene therapy has generated interest for the treatment of soft tissue malignancies. It offers the theoretical promise of delivering cytotoxic, immunomodulatory, or anti- angiogenic genes to produce proteins targeting tumour ... -
An in vivo study of utricular hair cell degeneration and regeneration following animoglycoside induced damage of the mammalian inner ear
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)The anatomy of the mammalian ear is similar between the different subspecies. This applies to the structure of the utricle in humans and in guinea pigs. Hence the choice of the guinea pig utricle allows any findings ... -
An investigation of risk factors for fracture in patients with osteoporosis and osteopaenia using biomechanical, biochemical and radiological assessments
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Osteoporosis is defined as a skeletal disorder characterised by compromised bone strength resulting in an increased risk for fracture. Hip fractures are the most common osteoporotic fracture in older adults and occur due ... -
Clinicopathological and inflammatory prognostic factors in non-small cell lung cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Lung cancer is the most common cause of cancer death worldwide. Despite improvements in diagnosis and treatments, the overall prognosis for patients with lung cancer remains poor and novel therapeutic approaches are required. ... -
Colorectal cancer screening
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Colorectal cancer is a major public health burden and is the most common cause of mortality from cancer in Europe. Over the last two decades robust evidence from randomised clinical trials and case-control series have ... -
Cutaneous changes in renal transplant recipients - is there a relationship between benign and malignant disease?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Renal transplant recipients are at an increased risk of many cutaneous diseases. The increased incidence of cutaneous malignancy is well recognised. Cutaneous infections and iatrogenic effects of immunosuppressive medications ... -
Exposure to reduced oxygenation following radiation exposure enhances the survival of prostate cancer cells in vitro: implications for radiation therapy delivery
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Introduction: Hypoxia is a common feature of prostate tumours; hypoxic cells are more radioresistance compared to oxygenated cells. Hypoxic radioresistance has also been shown to be related to the duration of hypoxia prior ... -
Factors modulating TLR2, TLR4 and HBD2 expression in respiratory epithelium in COPD
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)The innate immune response of the respiratory epithelium, employing mechanisms of germ-line encoded, genetically conserved pattern recognition to “non-self’ organisms, is an important component of host defence against ... -
Intestinal microsomal triglyceride transfer protein, promoter region polymorphisms and postprandial lipoproteins in Type 2 Diabetes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)Microsomal triglyceride transfer protein is an ancient lipid transfer protein responsible for the assembly of chylomicrons in the intestine and very low density lipoproteins in the liver. Common MTP gene promoter region ... -
Investigating the role of constitutively active truncated androgen receptor splice variants in prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine, 2012)The androgen receptor (AR) is fundamental for the growth and survival of normal and malignant prostate cells. Therefore, androgen deprivation therapy remains the first‐line treatment for disseminated disease, however, ... -
Investigation of ABO blood group expresser phenotype
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The aims of this project were to study the variability of the ABO blood group expression on human platelets and to explore the underlying molecular mechanisms. 541 Irish blood donors were studied. The recently described ... -
Investigation of gene amplification and expression in prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)The purpose of this thesis was to identify significant genetic amplifications and protein expression of a gene or genes that have not been recognised as overamplified to date in prostate cancer. Methods used: -- 1) ... -
Investigation of lymph node transplantation as therapy for breast cancer related lymphedema
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Humans have hundreds of lymph nodes, collections of which are found in the underarms, groin, neck, chest, and abdomen. They have long been considered 'neutral' elements in terms of lymph transport. An assumption has always ... -
Management of maternal HIV-1 infection in pregnancy : the experience of the GUIDE clinic
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)As of the end of 2007 there were an estimated 33.2 (30.6-36.1) million people worldwide living with HIV-1 or AIDS. Almost seven thousand new infections occurred ever day in 2007. Children under 15 years of age accounted ... -
Minimal residual disease in cancer of the oesophagus and gastro-oesophageal junction
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Epithelial tumours are the most common form of cancer and are responsible for the majority of cancer-related deaths in Western industrialized countries. Minimal residual disease following neo-adjuvant therapy or primary ... -
Obesity, insulin resistance and Type 2 Diabetes in young Irish people
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The epidemic of obesity in Irish youth, one of the highest ranking internationally, represents a major threat to public health. However, little is known of the metabolic and clinical characteristics of this cohort. I ... -
Post operative atrial fibrillation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Post operative atrial fibrillation is a common occurrence following all forms of cardiac surgery apart from heart transplantation. Coronary artery bypass is the commonest cardiac surgical procedure with more than 800,000 ... -
Renal function, cardiovascular disease and long term outcome in different cohorts of the Glasgow population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Over the past ten to fifteen years, the interaction between cardiovascular disease and chronic kidney disease (CKD) has come under increased scrutiny. Traditional cardiovascular risk factors are also associated with the ... -
Sleeping with the head [up] of the bed tilted up: physiology & therapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Orthostatic hypotension (OH) is common and affects people with increasing age and co-morbidity. It is associated with increased vascular risk, falls and dementia. While pharmacological and non-pharmacological treatments ... -
Syphilis and HIV co-infection in Dublin; strategies to enhance diagnosis, investigation and management
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Following historically low levels of reported cases of syphilis in Dublin in the 1990s there was a large outbreak of syphilis reported in 2001. Numerous interventions were implemented and the rates again decreased in 2003. ...