Browsing Clinical Medicine (Theses and Dissertations) by Sponsor "Trinity College Dublin (TCD)"
Now showing items 1-6 of 6
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Association of clinical phenotype and genetic burden in coeliac disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Coeliac disease (CD) is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to a gluten containing diet in genetically predisposed individuals. The clinical presentation of CD is highly ... -
Biological Characteristics of Gastroesophageal Junction Adenocarcinomas and their Clinical Correlates
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Gastroesophageal junction adenocarcinomas (GEJA) have increased in incidence in the Western world over the last 50 years, a trend largely attributed to lifestyle factors including obesity and gastroesophageal reflux disease. ... -
An exploration of the role of the clinical academic and strategies to sustain and build the clinical academic workforce
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background Clinical academics are critical to delivering high quality patient care and discovering new ways to treat disease (1), however the clinical academic workforce is shrinking (2-4). There is a need to clearly ... -
Exploring the effects of time-restricted eating as a novel intervention in patients with polycystic ovarian syndrome
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Polycystic ovarian syndrome (PCOS) is associated with hyperinsulinemia, insulin resistance and a high lifetime risk of developing type-2 diabetes mellitus. While many dietary interventions have been tested ... -
Immune Dysfunction and Inflammageing in NAFLD
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)With a global prevalence of 25-40%, non-alcoholic fatty liver disease (NAFLD) is fast becoming the commonest cause of liver disease in the developed world [1]. Defined as increased hepatic lipid accumulation, approximately ... -
Investigating the role of IL-36 cytokines in mediating angiogenesis and vascular permeability
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Neovascular blinding conditions including age related macular degeneration and diabetic retinopathy are the most common causes of blindness in the elderly and working age populations respectively. Currently the best-in-class ...