Browsing Clinical Medicine (Theses and Dissertations) by Sponsor "Science Foundation Ireland (SFI)"
Now showing items 1-10 of 10
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Characterisation of the efficacy of two novel host-directed therapies, SCD-19 and 4-octyl itaconate, for the treatment of Pseudomonas aeruginosa infection in cystic fibrosis.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Cystic Fibrosis (CF) is a life limiting genetic disease, which is caused by genetic mutations which result in defective function of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In CF, patients experience ... -
Characterisation of the role of IL-18 in neovascular AMD
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Age-related macular degeneration is the leading cause of vision loss in the over 50’s in developed countries, accounting for 8.7% of all blindness worldwide. AMD is a progressive disease affecting the macula region of the ... -
Defining the role of RORα in the functionality of distinct immune cell populations
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The transcription factor Retinoic acid-related Orphan Receptor (ROR)-a has roles in metabolism, circadian rhythm and cellular development, such as Th17 cells and group 2 innate lymphoid cells (ILC2). The identification ... -
Does the future of epilepsy care lie in eHealth? An examination of attitudes and behaviours towards epilepsy self-management and eHealth from the perspectives of people with epilepsy, their carers and healthcare providers
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022) -
Genetic Epidemiology and Cognitive Endophenotyping in Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Amyotrophic Lateral Sclerosis (ALS) is a progressive debilitating and ultimately fatal neurodegenerative disorder affecting both upper (UMN) and lower (LMN) motor neurons. While it has been long known to exist on a spectrum ... -
The impact of folate and vitamin B12 intake and biomarker status on cognitive performance in older adults on the island of Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: Some studies have reported that suboptimal B vitamin status has been negatively associated with cognition in older adults, though, not all studies have observed this. This is hampered by the lack of new and ... -
Investigating Molluscum Contagiosum Virus Protein MC008 and its Effect on Inflammatory Signalling
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Molluscum contagiosum virus (MCV) is a human-adapted poxvirus that causes a common, persistent, yet mild infection characterized by distinct, contagious, papular skin lesions. These lesions are notable for having little ... -
Investigating the role of IL-36 cytokines in mediating angiogenesis and vascular permeability
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Neovascular blinding conditions including age related macular degeneration and diabetic retinopathy are the most common causes of blindness in the elderly and working age populations respectively. Currently the best-in-class ... -
Predictive Microbiome Post-Bone Marrow Transplantation and Acute Graft versus Host Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Haemopoietic stem-cell transplantation serves as one of the life-saving options for the management of refractory haematological malignancies and rarely for non-malignant conditions. The era of transplantation has significantly ... -
The role of monocytes in ANCA associated vascultis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)ANCA associated vasculitis (AAV) encompasses several autoimmune conditions characterised by destruction of small vessels, inflammation of the respiratory tract, and glomerulonephritis. Most patients harbour autoantibodies ...