Browsing Clinical Medicine (Theses and Dissertations) by Sponsor "Health Research Board (HRB)"
Now showing items 1-12 of 12
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Adaptive immune response in human Staphylococcus aureus bloodstream infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Staphylococcus aureus bloodstream infection is a common and life-threatening condition. Treatment outcomes are poor, suboptimal clinical management is common, antimicrobial resistance continues to emerge, and there are few ... -
Characterising Macrophage Immunometabolism in Mycobacterium tuberculosis and HIV Co-Infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction Tuberculosis (TB) and HIV are leading infection-related causes of global mortality and result in an enormous amount of suffering and economic loss. Available TB treatment strategies are inadequate, and vaccination ... -
Deep phenotyping through biomarker profiling of frontotemporal dementia (FTD) with and without co-morbid motor neuron degeneration: A multidimensional approach
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)PhD Thesis abstract: Trinity College Dublin Title: Deep Phenotyping Through biomarker Profiling of Frontotemporal Dementia (FTD) With and Without Co-morbid Motor Neuron Degeneration: A Multidimensional Approach Authors: ... -
The Environmental Epidemiology of Amyotrophic Lateral Sclerosis in Europe
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Amyotrophic Lateral Sclerosis (ALS) is a terminal neuro-degenerative disorder of adults, typically having rapid progression and involving both motor and cognitive function. ALS exhibits considerable heterogeneity of both ... -
Evaluation of diagnostic and treatment strategies for the management of Helicobacter pylori infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Helicobacter pylori infection is responsible for chronic gastritis and the development of gastrointestinal disorders such as gastric or duodenal ulcers, gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) ... -
Examining the breadth and burden of chronic kidney disease in community-dwelling older adults
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Introduction: Chronic kidney disease (CKD), characterised by reductions in glomerular filtration rate (GFR), is associated with premature mortality and end stage kidney disease. Older adults have the highest prevalence of ... -
Investigating a role for TLR signalling and complement deposition in retinal degeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Age-related macular degeneration (AMD) and Retinitis Pigmentosa (RP) are the most common cause of progressive vision loss in the developed world. AMD is a multifactorial disease with both genetic and environmental risk ... -
Investigation of the monogenic causes of chronic kidney disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Chronic Kidney Disease (CKD) is a common chronic condition that affects 15 percent of adults in the Irish healthcare system. End stage kidney disease (ESKD) represents the final stage of CKD which culminates in the need ... -
Macrophage immunometabolism in the host response to Mycobacterium tuberculosis infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Tuberculosis (TB) is the leading infectious disease killer in the world, alongside HIV. Our understanding of the complex host immune response to Mycobacterium tuberculosis (Mtb) remains incomplete, but varied clinical ... -
Network Analysis in Amyotrophic Lateral Sclerosis during Voluntary Motor Task: Neurophysiological Biomarkers of Disrupted Cortical Connections
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease that causes degeneration of both upper and lower motor neurons primarily affecting the motor system, but individual people with ALS show ... -
Personalised Medicine in ANCA-Associated Vasculitis: The Role of Urine Soluble CD163
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)In this thesis I have identified a highly sensitive and specific association between urinary sCD163 and active renal vasculitis in the clinical setting of renal vasculitis flare in both retrospective and prospective studies. ... -
The role of angiopoietins and their mediators in symptomatic small bowel angiodysplasia; identifying novel diagnostic and therapeutic targets in chronic anaemia and obscure gastrointestinal bleeding
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Title : The role of angiopoietins and their mediators in symptomatic small bowel angiodysplasia; identifying novel diagnostic and therapeutic targets in chronic anaemia and obscure gastrointestinal bleeding. Author: Dr ...