Browsing Clinical Medicine (Theses and Dissertations) by Author "O'Connor, Lisa M."
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Development of an antisense strategy to down-regulate gene expression in chronic myelogenous leukaemia
O'Connor, Lisa M. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Since the discovery of mRNA down-regulation by sequences of complementary nucleic acids in 1977, there has been a drive to apply the antisense phenomenon to therapeutic settings. In theory the potential of antisense ...