Browsing Microbiology (Scholarly Publications) by Sponsor "Science Foundation Ireland"
Now showing items 1-5 of 5
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Complete bypass of restriction systems for major staphylococcus aureus lineages
(2015)Staphylococcus aureus is a prominent global nosocomial and community-acquired bacterial pathogen. A strong restriction barrier presents a major hurdle for the introduction of recombinant DNA into clinical isolates of S. ... -
Fibrinogen binding sites P336 and Y338 of clumping factor A are crucial for Staphylococcus aureus virulence.
(2008)We have earlier shown that clumping factor A (ClfA), a fibrinogen binding surface protein of Staphylococcus aureus, is an important virulence factor in septic arthritis. When two amino acids in the ClfA molecule, P336 and ... -
IL-33 and IL-18 in inflammatory bowel disease etiology and microbial interactions
(2019)The IL-1 cytokines are a newly expanded family, with each of its 11 members playing an important role in health and disease. Typically acting as pro- or anti-inflammatory mediators of first-line innate immunity, their ... -
Modelling staphylococcal pneumonia in a human 3D lung tissue model system delineates toxin-mediated pathology
(2015)Staphylococcus aureus necrotizing pneumonia is recognized as a toxin-mediated disease, yet the tissue-destructive events remain elusive, partly as a result of lack of mechanistic studies in human lung tissue. In this study, ... -
A potential new pathway for Staphylococcus aureus dissemination: silent survival of S.aureus phagocytosed by human monocyte-derived macrophages.
(2008)Although considered to be an extracellular pathogen, Staphylococcus aureus is able to invade a variety of mammalian, non-professional phagocytes and can also survive engulfment by professional phagocytes such as neutrophils ...