Browsing Biochemistry (Scholarly Publications) by Subject "Vaccine"
Now showing items 1-9 of 9
-
CD4 TRMcells following infection and immunization: Implications for more effective vaccine design
(2018)The induction of immunological memory, which is mediated by memory T and B cells, is central to adaptive protective immunity to pathogens induced by previous infection and is the cornerstone of effective vaccine design. ... -
Harnessing the antibacterial and immunological properties of mucosal-associated invariant T cells in the development of novel oral vaccines against enteric infections.
(2014)Enteric infections are a major cause of mortality and morbidity with significant social and economic implications worldwide and particularly in developing countries. An attractive approach to minimizing the impact of these ... -
Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines.
(2013)Vaccines that promote protective adaptive immune responses have been successfully developed against a range of infectious diseases, and these are normally administered prior to exposure with the relevant virus or bacteria. ... -
Modulation of immune responses using adjuvants to facilitate therapeutic vaccination
(2020)Therapeutic vaccination offers great promise as an intervention for a diversity of infectious and non-infectious conditions. Given that most chronic health conditions are thought to have an immune component, vaccination ... -
Nasal vaccines for pertussis
(2023)Whooping cough, caused by Bordetella pertussis, is still a major cause of morbidity and mortality worldwide. Current acellular pertussis (aP) vaccines induce potent circulating IgG and prevent severe disease in children/adults ... -
Next-generation anti-Staphylococcus aureus vaccines: A potential new therapeutic option for atopic dermatitis?
(2019)Disease severity in patients with atopic dermatitis (AD) isdirectly correlated with colonization by Staphylococcus aureus.1 An increasing body of evidence now also supports a role for Saureusin the pathogenesis of AD in ... -
A novel vaccine strategy employing serologically different chimpanzee adenoviral vectors for the prevention of HIV-1 and HCV coinfection
(2019)Background: Nearly 3 million people worldwide are coinfected with HIV and HCV. Affordable strategies for prevention are needed. We developed a novel vaccination regimen involving replication-defective and serologically ... -
An oral alpha-galactosylceramide adjuvanted Helicobacter pylori vaccine induces protective IL-1R- and IL-17R-dependent Th1 responses
(2019)Helicobacter pylori causes chronic gastric infection that can lead to peptic ulcers and is an identified risk factor for gastric cancer development. Although much effort has been put into the development of a Helicobacter ... -
TLR, NLR agonists, and other immune modulators as infectious disease vaccine adjuvants
(2010)Vaccines based on attenuated or killed viruses and bacteria are highly effective in preventing infection with a range of pathogens, but can have safety issues. Therefore, there is a move towards subunit vaccines based ...