Browsing Biochemistry (Scholarly Publications) by Subject "Nanoscience & Materials"
Now showing items 1-8 of 8
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Advances in immunotherapy for the treatment of glioblastoma.
(2017)Glioblastoma (GBM) is an aggressive brain tumour, associated with extremely poor prognosis and although there have been therapeutic advances, treatment options remain limited. This review focuses on the use of immunotherapy, ... -
Crystallization and preliminary X-ray diffraction analysis of a soluble domain of the putative zinc transporter CzrB from Thermus thermophilus
(2007)CzrB is a putative zinc transporter from Thermus thermophilus. The protein is proposed to consist of a hexahelical transmembrane domain with a cytosolic extramembranal C-terminus. The latter 92-residue fragment may be ... -
Direct correlation of structure changes and thermal events in hydrated lipid established by simultaneous calorimetry and time-resolved x-ray diffraction.
(1992)In many lipid systems, polymorphic and mesomorphic behavior depends on sample thermal history. To establish unequivocally the structural origin of endothermic and exothermic events in such systems, we have performed ... -
Multivalent presentation of MPL by porous silicon microparticles favors T helper 1 polarization increasing the anti-tumor efficacy of doxorubicin nanoliposomes
(2014)Porous silicon (pSi) microparticles, in diverse sizes and shapes, can be functionalized to present pathogen-associated molecular patterns that activate dendritic cells. Intraperitoneal injection of MPL-adsorbed pSi ... -
Structural Refinement of the OpcA Adhesin Using Molecular Dynamics.
(2007)OpcA from Neisseria meningitidis, the causative agent of meningococcal meningitis and septicemia, is an integral outer membrane protein that facilitates meningococcal adhesion through binding the proteoglycan receptors ... -
Unexpected roles for DEAD-box protein 3 in viral RNA sensing pathways
(2010)Detection of viral nucleic acid within infected cells is essential to an effective antiviral response. The retinoic acid-inducible gene-I (RIG-I)-like receptors (RLR) form part of the virus detection repertoire and are ... -
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome.
(2009)Many currently used and candidate vaccine adjuvants are particulate in nature, but their mechanism of action is not well understood. Here, we show that particulate adjuvants, including biodegradable poly(lactide-co-glycolide) ...