Browsing Biochemistry (Scholarly Publications) by Subject "Aging"
Now showing items 1-3 of 3
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Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver
(2021)5-Aminolevulinic acid (ALA) is the rate-limiting intermediate in heme biosynthesis in vertebrate species; a re- action catalyzed by the mitochondrial ALA synthase 1 (ALAS1) enzyme. Previously we reported that knockdown of ... -
Sestrins Link Tumor Suppressors with the AMPK -TOR Signaling Network
(InTech, 2012)The strength of the mechanisms involved in the control of health and lifespan determines the rate of aging in any organism. Aging is fueled by the accumulation of damage in a multitude of tissues, causing many age-related ... -
Stressin' Sestrins take an aging fight
(2010)Sestrins (Sesns) are a family of highly conserved stress‐responsive proteins, transcriptionally regulated by p53 and forkhead transcription factor that exhibit oxidoreductase activity in vitro and can protect cells from ...