Browsing Biochemistry (Scholarly Publications) by Author "WILLIAMS, DAVID"
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Novel Microtubule targetting agents, pyrrolo-1,5,benzoxazepines induce apoptosis in multi-drug-resistant cancer cells
LLOYD, DAVID; ZISTERER, DANIELA; WILLIAMS, DAVID; FAYNE, DARREN (2010)PURPOSE: The development of multi-drug resistance (MDR) due to the expression of members of the ATPase binding cassette (ABC) transporter family is a major obstacle in cancer treatment. The broad range of substrate ... -
Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents
MCNAMARA, YVONNE; WILLIAMS, DAVID; CLOONAN, SUZANNE; KNOX, ANDREW; MEEGAN, MARY (2011)Structural derivatives of 4-MTA, an illegal amphetamine analogue have been previously shown to have anticancer effects in vitro. In this study we report the synthesis of a series of novel 1,3-bis(aryl)-2-nitro-1-propene ...