Browsing Biochemistry (Scholarly Publications) by Author "SHEEDY, FREDERICK"
Now showing items 1-4 of 4
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IL-10 inhibits miR-155 induction by Toll-like receptors.
O'NEILL, LUKE; DOYLE, SARAH; MCCOY, CLAIRE; SHEEDY, FREDERICK JOHN; QUINN, SUSAN; SHEEDY, FREDERICK (2010)IL-10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes which are induced by Toll-like Receptor (TLR) signalling. In this study we have examined whether modulation of micro-RNAs ... -
Toll-like receptor 4 (TLR4) down-regulates microRNA-107 increasing macrophage adhesion via cyclin-dependent kinase 6
O'NEILL, LUKE; SHEEDY, FREDERICK (2011)Toll-like receptors (TLRs) modulate the expression of multiple microRNAs (miRNAs). Here we report the down-regulation of miR-107 by TLR4 in multiple cell types. The miR-107 sequence occurs in an intron within the sequence ... -
The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling
O'NEILL, LUKE; SHEEDY, FREDERICK (2007)Signaling by two of the most important bacteria-sensing TLRs, TLR2 and TLR4, involves two adaptor proteins, MyD88 adaptor-like (Mal) and Toll/IL-1 receptor (TIR) domain-containing adaptor-inducing IFN-? (Trif)-related ... -
Turning 21: Induction of miR-21 as a key switch in the inflammatory response
SHEEDY, FREDERICK (2015)miR-21 is one of the most highly expressed members of the small non-coding microRNA family in many mammalian cell types. Its expression is further enhanced in many diseased states including solid tumors, cardiac injury, ...