Browsing Biochemistry (Scholarly Publications) by Author "SCOTT, JOHN MARTIN"
Now showing items 1-14 of 14
-
Cobalamin, folic acid, and homocysteine
SCOTT, JOHN MARTIN (John Wiley, 2009)Cobalamin deficiency can lead to several adverse health consequences: folate trapping in the methylation cycle and subsequent impaired DNA biosynthesis; pernicious anemia hematologically, similar to that caused by folate ... -
A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (2009)Polymorphisms in folate-related genes have emerged as important risk factors in a range of diseases including neural tube defects (NTDs), cancer, and coronary artery disease (CAD). Having previously identified a polymorphism ... -
Facts and recommendations about total homocysteine determinations: an expert opinion
MCPARTLIN, JOSEPH; SCOTT, JOHN MARTIN (American Association for Clinical Chemistry, 2004)Background: Measurement of plasma total homocysteine has become common as new methods have been introduced. A wide range of disorders are associated with increased concentrations of total homocysteine. The purpose of this ... -
Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1.
SCOTT, JOHN MARTIN (Elsevier, 2009)Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that recruits monocytes into the subendothelial cell layer in atherosclerotic lesions. Elevated homocysteine (hyperhomocysteinemia), which is usually associated ... -
Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults
SCOTT, JOHN MARTIN (American Society of Hematology, 2003)A modestly elevated total plasma homocysteine concentration (tHcy) is generally accepted as an independent and graded risk factor for various pathologies, including vascular diseases, neural tube defects, Alzheimer disease, ... -
Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements
MCPARTLIN, JOSEPH; SCOTT, JOHN MARTIN (American Society for Clinical Nutrition, 2002)Background: Methylenetetrahydrofolate reductase (MTHFR; EC 1.7.99.5) supplies the folate needed for the metabolism of homocysteine. A reduction in MTHFR activity, as occurs in the homozygous state for the 677CT (so-called ... -
Lack of Association between Folate-Receptor Autoantibodies and Neural-Tube Defects
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (2009)Molloy AM, Quadros EV, Sequeira JM, Troendle JF, Scott JM, Kirke PN, Mills JL. `Lack of Association between Folate-Receptor Autoantibodies and Neural-Tube Defects? in New England Journal of Medicine, 361, (2), 2009, pp 152-160 -
Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (American Academy of Pediatrics, 2009)OBJECTIVE. Folic acid fortification has reduced neural tube defect prevalence by 50% to 70%. It is unlikely that fortification levels will be increased to reduce neural tube defect prevalence further. Therefore, it is ... -
Persistent circulating unmetabolised folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification?
SCOTT, JOHN MARTIN (BioMed Central, 2009)BACKGROUND: Ireland is an example of a country that has extensive voluntary fortification with folic acid. After a public consultation process, in 2006, the Food Safety Authority in Ireland FSAI 1 recommended mandatory ... -
Personalised nutrition Genetic variation and disease risk: new advances
SCOTT, JOHN MARTIN (Cambridge University Press, 2009)Variations in human DNA, most frequently single-nucleotide polymorphisms (SNPs), can have functional consequences ranging from severe to none. Variations in outcome (phenotype) can be compared, from cystic fibrosis through ... -
The pregnancy-related decrease in fasting plasma homocysteine is not explained by folic acid supplementation, hemodilution, or a decrease in albumin in a longitudinal study
MCPARTLIN, JOSEPH; SCOTT, JOHN MARTIN (American Society for Clinical Nutrition, 2002)Background: Fasting plasma total homocysteine (tHcy) decreases during pregnancy. Previous reports suggested that this is due to folic acid supplementation, hemodilution, or a decrease in albumin. However, these hypotheses ... -
The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women.
SCOTT, JOHN MARTIN (Wiley-Blackwell, 2009)Low folate status may be a consequence of suboptimal intake, transport or cellular utilization of folate and, together with elevated homocysteine, is a recognized risk factor or marker for several human pathologies. As ... -
Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation
SCOTT, JOHN MARTIN (American Association for Clinical Chemistry, 2002)Background: Vitamin B2 exists in blood as riboflavin and its cofactors, flavin mononucleotide (FMN) and FAD. The erythrocyte glutathione reductase activation coefficient (EGRAC) has traditionally been used to assess vitamin ... -
Screening for vitamin B-12 and folate deficiency in older persons
SCOTT, JOHN MARTIN (American Society for Clinical Nutrition, 2003)Background: Vitamin B-12 deficiency is usually accompanied by elevated concentrations of serum total homocysteine (tHcy) and methylmalonic acid (MMA). Folate deficiency also results in elevated tHcy. Measurement of these ...