Browsing Biochemistry (Scholarly Publications) by Author "KELLY, VINCENT"
Now showing items 1-5 of 5
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5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice
KELLY, VINCENT; Saitoh, Shinichi; Okano, Satoshi; Nohara, Hidekazu; Nakano, Hiroshi; Shirasawa, Nobuyuki; Naito, Akira; Yamamoto, Masayuki; Kelly, Vincent P.; Takahashi, Kiwamu; Tanaka, Tohru; Nakajima, Motowo; Nakajima, Osamu (2018)In vertebrates, the initial step in heme biosynthesis is the production of 5-aminolevulinic acid (ALA) by ALA synthase (ALAS). ALA formation is believed to be the rate-limiting step for cellular heme production. Recently, ... -
Queuine s influence on tetrahydrobiopterin and tyrosine metabolism
KELLY, VINCENT (2013) -
Queuosine deficiency in eukaryotes compromises tyrosine production through increased tetrahydrobiopterin oxidation.
KELLY, VINCENT; BERNSTEIN, IIANA; RAKOVICH, TATSIANA (2011)Queuosine is a modified pyrrolopyrimidine nucleoside found in the anticodon loop of transfer RNA acceptors for the amino acids tyrosine, asparagine, aspartic acid, and histidine. Since it is exclusively synthesised by ... -
Queuosine formation in eukaryotic tRNA occurs via a mitochondrial localized heteromeric transglycoslase.
KELLY, VINCENT (2009)tRNA guanine transglycosylase (TGT) enzymes are responsible for the formation of queuosine in the anticodon loop (position 34) of tRNAAsp, tRNAAsn, tRNAHis, and tRNATyr; an almost universal event in eubacterial and eukaryotic ... -
Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha
MCGETTRICK-DILLON, ANNE; CORR, SINEAD; PALSSON, EVA; KELLY, VINCENT; O'NEILL, LUKE (2013)Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch their core metabolism from oxidative phosphorylation to glycolysis. Here we show that inhibition of glycolysis with 2-deoxyglucose ...