Browsing Biochemistry (Scholarly Publications) by Author "Gardiner, Clair"
Now showing items 1-5 of 5
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Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
Finlay, David; Gardiner, Clair (2018) -
Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection.
Gardiner, Clair; O'Farrelly, Cliona; Mc Kiernan, Susan (2011)Hepatitis C is a common infection with significant morbidity and mortality, and only a minority of patients successfully clear the infection. Identification of factors that influence disease progression in HCV infection ... -
NK Cell Metabolism and TGFβ – Implications for Immunotherapy
Gardiner, Clair; Slattery, Karen (2019)NK cells are innate lymphocytes which play an essential role in protection against cancer and viral infection. Their functions are dictated by many factors including the receptors they express, cytokines they respond to ... -
A novel vaccine strategy employing serologically different chimpanzee adenoviral vectors for the prevention of HIV-1 and HCV coinfection
Gardiner, Clair; Hartnell, Felicity; Brown, Anthony; Capone, Stefania; Kopycinski, Jakub; Bliss, Carly; Makvandi-Nejad, Shokouh; Swadling, Leo; Ghaffari, Emma; Cicconi, Paola; Del Sorbo, Mariarosaria; Sbrocchi, Roberta; Esposito, Ilaria; Vassilev, Ventzislav; Marriott, Paula; Bannan, Ciaran; Bergin, Colm; Hoffmann, Matthias; Turner, Bethany; Nicosia, Alfredo; Folgori, Antonella; Hanke, Tomáš; Barnes, Eleanor; Dorrell, Lucy (2019)Background: Nearly 3 million people worldwide are coinfected with HIV and HCV. Affordable strategies for prevention are needed. We developed a novel vaccination regimen involving replication-defective and serologically ... -
Suppression of Natural Killer cell NKG2D and CD226 anti-tumour cascades by platelet cloaked cancer cells: Implications for the metastatic cascade
Gardiner, Clair; O'Toole, Sharon; Sheils, Orla (2019)Tumour cell immune evasion is a principal hallmark of successful metastasis. Tumour cells in the vasculature adopt a platelet cloak that efficiently suppresses the innate immune system by directly inhibiting Natural Killer ...