Browsing Biochemistry (Scholarly Publications) by Author "Ding, Boxiao"
Now showing items 1-2 of 2
-
Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death
Budanov, Andrei; Ding, Boxiao; Parmigiani, Anita; Divakaruni, Ajit S.; Archer, Kellie; Murphy, Anne N. (2016)Sestrin2 is a member of a family of stress responsive proteins, which controls cell viability via antioxidant activity and regulation of the mammalian target of rapamycin protein kinase (mTOR). Sestrin2 is induced by ... -
Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Budanov, Andrei; Parmigiani, Anita; Nourbakhsh, Aida; Ding, Boxiao; Wang, Wei; Kim, Young Chul; Akopiants, Konstantin; Guan, Kun-Liang; Karin, Michael (2014)The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a sensor of different environmental conditions and regulator of cell growth, metabolism, and autophagy. mTORC1 is activated by Rag GTPases, working as RagA:RagB ...