Browsing Biochemistry (Scholarly Publications) by Author "Canavan, Mary"
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Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14.
O'Neill, Luke; Doyle, Sarah; Canavan, Mary (2013)Polyunsaturated fatty acids (PUFA) can modulate the immune response, however the mechanism by which they exert this effect remains unclear. Previous studies have clearly demonstrated that the cis-9, trans-11 isomer of ... -
Enriched CD141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis.
Fletcher, Jean; Fearon, Ursula; Moran, Barry; Canavan, Mary (2018)CD141+ DC are implicated in antiviral and antitumor immunity. However, mechanisticstudies in autoimmune disease are limited. This is the first study to our knowledgeexamining CD141+ DC in autoimmune disease, specifically ... -
Omega-3 fatty acids attenuate dendritic cell function via NF-kappa B independent of PPAR gamma
Mills, Kingston; Canavan, Mary (2011)Long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) have been shown to modulate the immune response and have therapeutic effects in inflammatory disorders. PUFA are also peroxisome proliferators-activator receptor-gamma ...