Browsing Biochemistry (Scholarly Publications) by Author "Basdeo, Sharee"
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The Effects of Trained Innate Immunity on T Cell Responses; Clinical Implications and Knowledge Gaps for Future Research
Mills, Kingston; Basdeo, Sharee (2021)The burgeoning field of innate immune training, also called trained immunity, has given immunologists new insights into the role of innate responses in protection against infection and in modulating inflammation. Moreover, ... -
IL-27 mediates the response to IFN beta therapy in multiple sclerosis patients by inhibiting Th17 cells
Fletcher, Jean; Basdeo, Sharee; Mills, Kingston (2011)Interferon (IFN)-? is a commonly used therapy for relapsing remitting multiple sclerosis (RRMS). However its protective mechanism is still unclear and the failure of many patients to respond has not been explained. We have ... -
Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation
Dunne, Aisling; Fletcher, Jean; Creagh, Emma; Basdeo, Sharee (2016)The main limitation to successful transplantation is the antigraft response developed by the recipient immune system, and the adverse side effects of immunosuppressive agents which are associated with significant toxicity ...