Browsing Biochemistry (Scholarly Publications) by Title
Now showing items 704-723 of 725
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UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation
(2020)Uncoupling proteins (UCPs) are members of the mitochondrial anion carrier superfamily that can mediate the transfer of protons into the mitochondrial matrix from the intermembrane space. We have previously reported UCP3 ... -
Uncoupling mechanism and redox regulations of mitochondrial uncoupling protein UCP1
(2018)Brown adipose tissue (BAT) and brown in white (brite) adipose tissue, termed also beige adipose tissue, are major sites of mammalian nonshivering thermogenesis. Mitochondrial uncoupling protein 1 (UCP1), specific for these ... -
Unexpected roles for DEAD-box protein 3 in viral RNA sensing pathways
(2010)Detection of viral nucleic acid within infected cells is essential to an effective antiviral response. The retinoic acid-inducible gene-I (RIG-I)-like receptors (RLR) form part of the virus detection repertoire and are ... -
Unravelling the immunomodulatory effects of viral ion channels, towards the treatment of disease
(2021)The current COVID-19 pandemic has highlighted the need for the research community to develop a better understanding of viruses, in particular their modes of infection and replicative lifecycles, to aid in the development ... -
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome.
(2009)Many currently used and candidate vaccine adjuvants are particulate in nature, but their mechanism of action is not well understood. Here, we show that particulate adjuvants, including biodegradable poly(lactide-co-glycolide) ... -
Use of a Robot for High-throughput Crystallization of Membrane Proteins in Lipidic Mesophases
(2012)An important route to understanding how proteins function at a mechanistic level is to have the structure of the target protein available, ideally at atomic resolution. Presently, there is only one way to capture such ... -
Vaccine trials during a pandemic: potential approaches to ethical dilemmas
(2021)Ever since the emergence of the coronavirus disease 2019 (COVID-19), global public health infrastructures and systems, along with community-wide collaboration and service, have risen to an unprecedented challenge. ... -
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence
(2005)Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses. Here, we define the function ... -
Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7
(2011)Recognition of viruses by pattern recognition receptors (PRRs) causes interferon-? (IFN-?) induction, a key event in the anti-viral innate immune response, and also a target of viral immune evasion. Here the vaccinia virus ... -
Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection
(2010)CD209, a c-type lectin expressed by dendritic cells (DCs), acts as a pathogen recognition receptor. A single nucleotidepolymorphism (SNP) in the promoter region of CD209(-336A/G;rs4804803) affects transcription and is ... -
A variant in the CD209 promoter is associated with the severity of liver disease in chronic Hepatitis C virus infection
(2010)CD209, a c-type lectin expressed by dendritic cells (DCs) acts as a pathogen recognition receptor. A single nucleotide polymorphism (SNP) in the promoter region of CD209 (-336 A/G; rs4804803) affects transcription and is ... -
Variation in Both IL28B and KIR2DS3 Genes Influence Pegylated Interferon and Ribavirin Hepatitis C Treatment Outcome in HIV-1 Co-Infection
(2013)Pegylated-IFN and ribavirin remains the current treatment for chronic HCV infection in patients co-infected with HIV-1, but this regimen has low efficacy rates, particularly for HCV genotype 1/4 infection, has severe side ... -
Viral Inhibitory Peptide of TLR4, a Peptide Derived from Vaccinia Protein A46, Specifically Inhibits TLR4 by Directly Targeting MyD88 Adaptor-Like and TRIF-Related Adaptor Molecule
(2010)TLRs are critical pattern recognition receptors, which recognize bacterial and viral pathogen associated molecular patterns leading to innate and adaptive immune responses. TLRs signal via homotypic interactions between ... -
Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase
(2000)The transcription factor NF-kappaB is a central mediator of altered gene expression during inflammation, and is implicated in a number of pathologies, including cancer, atherosclerosis, and viral infection. We report in ... -
The Warburg effect then and now: From cancer to inflammatory diseases
(2013)Inflammatory immune cells, when activated, display much the same metabolic profile as a glycolytic tumor cell. This involves a shift in metabolism away from oxidative phosphorylation towards aerobic glycolysis, a phenomenon ... -
Worsening Cognitive Impairment and Neurodegenerative Pathology Progressively Increase Risk for Delirium.
(2015)Background Delirium is a profound neuropsychiatric disturbance precipitated by acute illness. Although dementia is the major risk factor this has typically been considered a binary quantity (i.e., cognitively impaired ... -
Would hemodialysis patients benefit from a Staphylococcus aureus vaccine?
(2019)Staphylococcus aureus bloodstream infection can have potentially catastrophic consequences for patients on hemodialysis. Consequently, an effective vaccine to prevent S aureus infection would have a significant influence ... -
X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex
(2016)Serial femtosecond X-ray crystallography (SFX) using an X-ray free electron laser (XFEL) is a recent advancement in structural biology for solving crystal structures of challenging membrane proteins, including G-protein ...