Browsing Biochemistry (Scholarly Publications) by Title
Now showing items 447-466 of 725
-
Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner
(2020)Engineering a pro-regenerative immune response following scaffold implantation is integral to functional tissue regeneration. The immune response to implanted biomaterials is determined by multiple factors, including ... -
Nasal vaccines for pertussis
(2023)Whooping cough, caused by Bordetella pertussis, is still a major cause of morbidity and mortality worldwide. Current acellular pertussis (aP) vaccines induce potent circulating IgG and prevent severe disease in children/adults ... -
Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke.
(2010)Background: Obese individuals who smoke have a 14 year reduction in life expectancy. Both obesity and smoking are independantly associated with increased risk of malignancy. Natural killer cells (NK) are critical mediators ... -
Natural Killer cells integrate signals received from tumour interactions and IL2 to induce robust and prolonged anti-tumour and metabolic responses
(2019)Natural Killer (NK) cells are lymphocytes with an important role in anti-tumour responses. NK cells bridge the innate and adaptive arms of the immune system; they are primed for immediate anti-tumour function but can also ... -
Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice
(2013)A subacute inflammatory phenotype is implicated in the pathology of insulin resistance (IR) and type 2 diabetes mellitus. Interleukin (IL)-1α and IL-1β are produced by innate immune cells, including macrophages, and mediate ... -
Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro.
(2012)Background: The innate immune response in the brain is initiated by pathogen-associated molecular patterns (PAMPS) or danger-associated molecular patterns (DAMPS) produced in response to central nervous system (CNS) infection ... -
Neutrophils: Need for Standardized Nomenclature
(2021)Neutrophils are the most abundant innate immune cell with critical anti-microbial functions. Since the discovery of granulocytes at the end of the nineteenth century, the cells have been given many names including phagocytes, ... -
New horizons in the pathogenesis, assessment and management of delirium.
(2013)Delirium is one of the foremost unmet medical needs in healthcare. It affects one in eight hospitalised patients and is associated with multiple adverse outcomes including increased length of stay, new institutionalisation, ... -
New insights into the regulation of TLR signaling
(Society of Leukocyte Biology, 2006)Toll-like receptor (TLR) activation is dictated by a number of factors including the ligand itself and the localization of the receptor, in terms of expression profile and subcellular localization and the signal transduction ... -
Next generation SARM1 knockout and epitope tagged CRISPR-Cas9-generated isogenic mice reveal that SARM1 does not participate in regulating nuclear transcription, despite confirmation of protein expression in macrophages
(2021)ABSTRACT SARM1 is an ancient and highly conserved TIR-domain containing protein, with a diverse range of proposed roles in both innate immunity and neuronal death and degeneration. Murine SARM1 has been reported to ... -
Next Generation Sequencing Reveals the Expression of a Unique miRNA Profile in Response to a Gram-Positive Bacterial Infection
(2013)MicroRNAs (miRNAs) are short, non-coding RNAs, which post-transcriptionally regulate gene expression and are proposed to play a key role in the regulation of innate and adaptive immunity. Here, we report a next generation ... -
Next Generation Sequencing Reveals the Expression of a Unique miRNA Profile in Response to a Gram-Positive Bacterial Infection.
(2013)MicroRNAs (miRNAs) are short, non-coding RNAs, which post-transcriptionally regulate gene expression and are proposed to play a key role in the regulation of innate and adaptive immunity. Here, we report a next generation ... -
Next-generation anti-Staphylococcus aureus vaccines: A potential new therapeutic option for atopic dermatitis?
(2019)Disease severity in patients with atopic dermatitis (AD) isdirectly correlated with colonization by Staphylococcus aureus.1 An increasing body of evidence now also supports a role for Saureusin the pathogenesis of AD in ... -
Next-generation pertussis vaccines based on the induction of protective t cells in the respiratory tract
(2020)Immunization with current acellular pertussis (aP) vaccines protects against severe pertussis, but immunity wanes rapidly after vaccination and these vaccines do not prevent nasal colonization with Bordetella pertussis. ... -
NF-kappaB activation by the Toll-IL-1 receptor domain-containing protein Mal is regulated by caspase-1
(2007)Toll-like receptors (TLRs)-2 and -4 are important proteins in innate immunity, recognizing microbial products and eliciting host defense responses. Both use the adapter proteins MyD88 and MyD88 adapter-like (Mal) to activate ... -
NK Cell Metabolism and TGFβ – Implications for Immunotherapy
(2019)NK cells are innate lymphocytes which play an essential role in protection against cancer and viral infection. Their functions are dictated by many factors including the receptors they express, cytokines they respond to ... -
NK cells and psoriasis.
(2011)Psoriasis is a chronic condition of the skin characterised by distinctive scaly plaques. The immune system is now thought to play a major role in the development and pathogenesis of psoriasis with immune cells and cytokines ...
