Browsing Biochemistry (Scholarly Publications) by Title
Now showing items 277-296 of 725
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Identification and Characterization of a Stage Specific Membrane Protein Involved in Flagellar Attachment in Trypanosoma brucei
(2013)Flagellar attachment is a visibly striking morphological feature of African trypanosomes but little is known about the requirements for attachment at a molecular level. This study characterizes a previously undescribed ... -
Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL.
(2004)We detected a protein in rabbit skeletal muscle extracts that was phosphorylated rapidly by PKB ? (protein kinase B ? ), but not by SGK1 (serum- and glucocorticoid-induced kinase 1), and ident- ified it as the ... -
Identification of Plasmepsin Inhibitors as Selective Antimalarial Agents using Ligand Based Drug Design
(Elsevier, 2011)We describe the application of Ligand Based Virtual Screening technologies towards the discovery of novel Plasmepsin (PM) inhibitors, a family of malarial parasitic aspartyl proteases. Pharmacophore queries were used to ... -
IFI16 is an innate immune sensor for intracellular DNA
(2010)The detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA ... -
IFNL cytokines do not modulate human or murine NK cell functions
(2014)The interferon-lambda (IFNL) cytokines have been shown to be important in HCV infection with SNPs in the IFNL3 gene associated with both natural and treatment induced viral clearance. We have recently shown that rs1299860 ... -
IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections.
(2017)IL-10 is a potent anti-inflammatory mediator that plays a crucial role in limiting host immunopathology during bacterial infections by controlling effector T cell activation. Staphylococcus aureus has previously been shown ... -
IL-17 and IL-17-producing cells in protection versus pathology
(2023)IL-17 cytokine family members have diverse biological functions, promoting protective immunity against many pathogens but also driving inflammatory pathology during infection and autoimmunity. IL-17A and IL-17F are produced ... -
IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F + neutrophils
(2021)Understanding the mechanism of protective immunity in the nasal mucosae is central to the design of more effective vaccines that prevent nasal infection and transmission of Bordetella pertussis. We found significant ... -
Immune modulation: IL-1, master mediator or initiator of inflammation
(2009)Interleukin-1 (IL-1) lies at the center of the inflammatory response. This proinflammatory cytokine was first pinned down for its ability to induce fever, and was later assigned additional biological functions including ... -
Immunization with whole cell but not acellular pertussis vaccines primes CD4 T <inf>RM</inf> cells that sustain protective immunity against nasal colonization with Bordetella pertussis
(2019)Protective immunity wanes rapidly after immunization of children with acellular pertussis (aP) vaccines and these vaccines do not prevent nasal colonization or transmission of Bordetella pertussis in baboons. In this study, ... -
Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology
(2019)Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for ... -
Immunometabolism and Natural Killer cell responses
(2019)Natural killer (NK) cells are lymphocytes with important roles in innate and adaptive immune responses to tumours and viral infection. However, in certain chronic diseases, including obesity and cancer, NK cell functional ... -
Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-Curie innovative training network
(2020)The past century has witnessed major advances in the control of many infectious diseases, yet outbreaks and epidemics caused by (re-) emerging RNA viruses continue to pose a global threat to human health. As illustrated ... -
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation
(2020)The Krebs cycle-derived metabolite itaconate is highly upregulated in inflammatory macrophages and exerts immunomodulatory effects through cysteine modifications on target proteins. The NLRP3 inflammasome, which cleaves ...