Browsing Biochemistry (Theses and Dissertations) by Sponsor "Irish Research Council (IRC)"

Now showing items 1-13 of 13

    • Characterisation of Membrane Glycoproteins that are Essential for Flagellar Attachment in the Bloodstream Form of Trypanosoma brucei 

      MCATEER, LOUISE (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)
      The African trypanosome, Trypanosoma brucei, is a unicellular parasitic protist that causes a severe disease, trypanosomiasis, in humans and livestock in sub-Saharan Africa. The trypanosome has a single flagellum that ...

    • CRISPR Gene Editing Approaches in the Study of Allergy and Infertility 

      BROWNING, JILL ADRIENNE (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)

    • Cyclosporine A modulates CD103+ DC responses to fungal PAMPs 

      Liddicoat, Alex (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
      Cyclosporine A (CsA) is an immunosuppressant that protects against inflammatory diseases and graft rejection. Despite its strong efficacy, one side-effect of CsA is an increased risk of fungal infection. To minimise this, ...

    • Investigation of the PTP4A3 oncogene and how it mechanistically regulates autophagy in ovarian cancer 

      Lopez Garza, Ana (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)
      Ovarian cancer has the highest mortality rates of all gynaecologic malignancies. High mortality rates are associated with poor levels of early detection due to asymptomatic tumour growth and limited screening programmes. ...

    • Modulation of immune responses by Fasciola hepatica-derived products 

      WALSH, ROBERT JAMES (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
      Helminths are successful pathogens that infect 25% of the world s population. They cause chronic infections that are associated with type-2 and regulatory immune responses that suppress host anti-parasite immune responses. ...

    • Modulation of macrophage responses by the vaccine adjuvant alum 

      GORMAN, AOIFE LOUISE LOUISE (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)
      Recent findings have challenged the classical view of innate versus adaptive immunity, suggesting that innate cells can retain some memory of past immunological insults. This trained immunity which allows for primed cellular ...

    • NMR Spectroscopic Characterization of Proteins Large and Small: Aggregates, Oligomers, and Peptides 

      KIM, JI YOON (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
      Nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful techniques for the investigation of structural, dynamic properties and interactions of biomolecules at the atomic level. In this thesis, by using ...

    • PATHOGENIC PROTEIN AGGREGATION IN VIVO AND IN VITRO 

      Fortunati, Daniel (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
      Neurodegenerative disorders (ND) such as Alzheimer?s disease (AD), Parkinson?s disease (PD) and amyotrophic lateral sclerosis (ALS) are one of the leading causes of death and disabilities worldwide. While their aetiologies ...

    • Pre-clinical development of NOX2/ROS blood-based biomarker of TBI 

      Emediato, Isabella Dias (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
      There is an urgent need to develop predictive biomarkers for traumatic brain injury (TBI) to aid clinical diagnosis and treatment of head injury patients. NADPH oxidase 2 (NOX2) activity and oxidized biomarkers are being ...

    • The role of Colony Stimulating Factor 1 Receptor in microglial phenotype and function in vitro and in vivo 

      Islam, Sadia (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
      As the brain ages multiple cellular processes become less efficient leading to a decline in cognitive and other functions, and in many cases giving rise to chronic neurodegenerative conditions such as Alzheimer’s Disease ...

    • The role of dietary fat in anti-tumour immunity 

      Prendeville, Hannah Catherine (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
      Obesity increases the risk of many cancers and impairs immunosurveillance. However, little is known about whether the type of dietary fat affects tumour growth and anti-tumour immune responses. Here, we show that a ...

    • A Study of Mitochondrial Dynamics and Glycosylation Events in PC12 Cells and Neurons 

      O HARA, DARREN (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017)
      Summary Mitochondrial dysfunction is recognised as a hallmark of many neurodegenerative diseases. Altered electron transport chain (ETC) complex activities, mitochondrial fusion/fission dynamics, mitochondrial motility ...

    • Tumour derived microRNA-21 reprograms macrophage responses 

      Case, Sarah (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
      The role of the oncogenic yet anti-inflammatory microRNA-21 (miR-21) in the tumour microenvironment (TME) is not clearly defined, despite its upregulation in many cancers. Since re-education of macrophages by tumour derived ...