Browsing Biochemistry (Theses and Dissertations) by Sponsor "Irish Research Council"

Now showing items 1-5 of 5

    • Adaptive Expression of Forgotten Engrams 

      Autore, Livia (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)
      Long-term memories are stored as stable configurations of neuronal ensembles, termed engrams. While investigation of engram cell properties and functionality in memory recall has been extensive, less is known about how ...

    • Investigation of Staphylococcus aureus-induced immunosuppression during nasal colonisation and the implications for vaccine function 

      Kelly, Alanna (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)
      Staphylococcus aureus (S. aureus) is a major part of the natural human microbiome, primarily colonising the anterior nares. The overall aim of this project was to determine the impacts nasal colonisation has on local and ...

    • Metabolic and redox regulation of IL-17-producing γδ T cells 

      Cunningham, Stephen (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)
      Interleukin-17 (IL-17) is a proinflammatory cytokine that contributes to a wide range of immune responses, including host defence, tissue repair, autoimmune inflammation, and tumour progression. γδ17 T cells (CD3+TCRδ+CD27-) ...

    • Particulate adjuvants for use in cancer vaccination 

      Ward, Ross (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)
      It is estimated that 1 in 2 people will develop cancer in their lifetime, highlighting the urgent need for improved preventative and therapeutic strategies. Cancer immunotherapy has emerged as a key pillar of cancer ...

    • Understanding the mechanism and functional effects of caspase-11 regulated nitric oxide production during inflammation and cancer 

      Nulty, Ciara (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)
      Inflammatory caspases are a group of cysteine aspartic proteinases essential for the inflammatory process, but when dysregulated are implicated in inflammatory diseases and cancer-associated chronic inflammatory events. ...