Recently, a novel series of Pyrrolo-1,5-BenzOXazepine (PBOX) compounds have shown apoptotic activity upon numerous cancer cell lines. Importantly, they have been suggested as potential antineoplastic agents in particular ...

While many licensed vaccines consist of whole or inactivated pathogens, there is a move toward vaccines based on purified antigens which although safer are generally less immunogenic and therefore require adjuvants to ...

The main objective of this study was to examine novel methods of inducing regulatory T (Treg) cells by modulating dendritic cell (DC) activation. It has previously been reported that TLR agonists stimulate IL-12 production ...

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterised by deposits of amyloid-β (Aβ) and neurofibrillary tangles. It has been suggested that inflammatory changes are associated with disease, ...

Uncoupling proteins (UCPs) are members of the mitochondrial anion carrier superfamily that can mediate the transfer of protons into the mitochondrial matrix from the intermembrane space. Our laboratory has reported evidence ...

Whooping cough (pertussis) is a severe respiratory disease cause by the Gram-negative bacterium Bordetella pertussis. Despite high vaccine coverage, a resurgence of pertussis has been observed over recent years. Although ...

Photodynamic therapy (PDT) represents a new localised method of treatment in cancer. The therapeutic effect is mediated by the generation of reactive oxygen species (ROS) and/or the formation of singlet oxygen (1 O2), a ...

This thesis investigated the behavior of semicarbazide sensitive amine oxidase (SSAO) and the unique activity that it possesses towards 5-hydroxytryptamine (5-HT) in various dental pulp tissues. This summary presents the ...