Browsing Biochemistry (Theses and Dissertations) by Title
Now showing items 198-217 of 290
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Oxysterols - new players in regulation of Natural Killer cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Natural Killer (NK) cells are cytotoxic, innate lymphocytes that play a crucial role in mediating viral and tumour responses as well as supporting tissue homeostasis. Due to their fast acting immune response independent ... -
Polymorphisms in members of the Toll-like receptor signalling pathway and their role in infectious disease
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)Toll-like receptors (TLRs) play an important role in mediating the host's response to invading pathogens. In humans, they comprise of a family of ten pattern recognition receptors (PRRs) located on innate immune cells. ... -
Rational discovery of second generation anti-cancer ligands
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)Recently, a novel series of Pyrrolo-1,5-BenzOXazepine (PBOX) compounds have shown apoptotic activity upon numerous cancer cell lines. Importantly, they have been suggested as potential antineoplastic agents in particular ... -
Regulation of innate and adaptive immune responses by synthetic and pathogen-derived immunomodulatory molecules
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)The development of new and improved vaccine formulations for human use requires the discovery of efficacious non-toxic adjuvants that enhance immune responses to poorly immunogenic purified native or recombinant antigens. ... -
Regulation of innate and adaptive immunity by the vaccine adjuvant alum
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)While many licensed vaccines consist of whole or inactivated pathogens, there is a move toward vaccines based on purified antigens which although safer are generally less immunogenic and therefore require adjuvants to ... -
Regulation of the immunomodulatory cytokine IL-10 by Twist2
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)Dysregulation of cytokines can lead to infectious and inflammatory diseases. The anti-inflammatory cytokine IL-10 is known to control pro-inflammatory cytokines such as TNF-a, IL-6 and IL-12. The regulation of IL-10 is ... -
Regulatory T cell induction and function
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)The main objective of this study was to examine novel methods of inducing regulatory T (Treg) cells by modulating dendritic cell (DC) activation. It has previously been reported that TLR agonists stimulate IL-12 production ... -
Role of infection and T cells in disease pathogenesis in a model of Alzheimer's disease
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Alzheimer's disease (AD) is a progressive neurodegenerative disease characterised by deposits of amyloid-β (Aβ) and neurofibrillary tangles. It has been suggested that inflammatory changes are associated with disease, ... -
The Role of miR-155 in Myeloid cells during Experimental Autoimmune Encephalomyelitis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterised by multifocal demyelinating lesions with associated neuronal damage. Although MS is a CD4+ T cell-mediated disease, ... -
The Role of Mitochondrial Uncoupling Protein 3 in T Cell Function
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)Uncoupling proteins (UCPs) are members of the mitochondrial anion carrier superfamily that can mediate the transfer of protons into the mitochondrial matrix from the intermembrane space. Our laboratory has reported evidence ...
