Browsing Biochemistry (Theses and Dissertations) by Title
Now showing items 95-114 of 290
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Identification and characterisation of proteins from the tomato lectin binding fraction of Trypanosoma brucei
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)African trypanosomes, of which Trypanosoma brucei may be considered a prototypic member, are protozoan parasites responsible for sleeping sickness in man and related diseases in cattle and other domestic animals. Although ... -
Identification and characterisation of serotonin transporter interacting proteins
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)The serotonin transporter (SERT) is an integral plasma membrane protein that mediates the high-affinity re-uptake of the neurotransmitter serotonin from the synaptic space. SERT is of particular clinical and phannacological ... -
Identification of Anticoagulant Properties of Dimethyl Fumarate and 4-Octyl Itaconate via Suppression of the Macrophage Type I Interferon-Tissue Factor Axis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The host response to infection is characterized by activation of the innate immune and blood coagulation systems, which collectively detect, neutralize, and prevent dissemination of the invading pathogen, maintaining ... -
Identification of novel innate immune mechanisms regulating oesophageal adenocarcinoma (OAC) progression and bacterial infection
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Inflammation is an essential immune system response to pathogens, damaged cells and stress stimuli and has an essential role in tissue repair and regeneration. The inflammatory response is the coordinated activation of ... -
Identification of the components of the eukaryotic queuine transglycosylase complex and the effect of its substrate queuine on metabolism
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Queuine is a 7-deazaguanine derivative of guanine, which replaces guanine in position 34 of the anticodon loop of the transfer RNA for the amino acids, asparagine, aspartic acid, histidine and tyrosine. This base or related ... -
Identification of the mammalian queuine transfer RNA ribosyltransferase complex and characterisation of QTRT1 gene-trap mice deficient in queuosine modified transfer RNA
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Queuine, or Q-base, is a modified form of 7-deazaguanine that is synthesised de novo by eubacteria, but which is obtained from food or the gut flora by eukaryotes. Q-base is enzymatically inserted into the wobble position ... -
IL-33 regulates the immune response to particulate vaccine adjuvants
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Vaccines are one of the most successful tools contributing to global health. Despite their success, further research into safe and efficient vaccination is required to address two key issues; to combat emerging infectious ... -
Immediate-Early-Gene (IEG) expression in excitotoxicity
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)The mouse cerebellar granule cell system (mCGCs; Schousboe et al, 1989) was established in this laboratory (Bayer AG, Germany) as a suitable cell culture model for excitotoxicity studies. Suitability was confirmed by ... -
Immune dysfunction in the skin disease hidradenitis suppurativa
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin disease. Painful lesions and boils present at hair follicles of the inframammary fold, genitals, groin, buttocks and perianal areas. Severe cases ... -
Immune modulation by the helminth parasite Fasciola hepatica
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)The incidence of allergic and autoimmune disease In the developed world has Increased dramatically In the past century. This has coincided with a reduction In the Incidence of infectious disease. The hygiene hypothesis ... -
Immune regulation by interferon-beta in multiple sclerosis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Interferon (IFN)-β is a commonly used therapy for patients with relapsing remitting multiple sclerosis (RRMS). Although IFN-β has been shown to exert various immunomodulatory effects, the therapeutic mechanisms are still ... -
Immunity and immune evasion in Hepatitis C virus infection
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)Hepatitis C virus (HCV) is an RNA virus which chronically infects an estimated 200 million people worldwide. Infection with HCV proceeds to chronicity in 80% of cases, and can be associated with the development of liver ... -
The immunmodulatory properties of chitin-derived polymers are dictated by their deacetylation patterns
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)The introduction of vaccines is regarded as one of the most successful medical interventions to date, due to their effectiveness at combating diseases that require the induction of a robust immune response. However there ... -
Immunomodulatory activity of products from the helminth parasite Fasciola hepatica
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Helminths have evolved strategies to evade host immune responses and these have been shown to be associated with simultaneous subversion of immune responses towards bystander antigens. This phenomenon forms the basis of ... -
The Immunomodulatory Metabolite Itaconate Regulates NLRP3 Inflammasome Activation and Type I Interferon Signalling
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)The NLRP3 inflammasome is a multi-protein complex which activates caspase-1 for the cleavage and release of mature IL-1β and IL-18. Caspase-1 also cleaves gasdermin D, driving a process called pyroptosis. Results from ... -
Immunomodulatory properties of endogenous danger signals
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)The 'danger model' proposes that dying cells release specific endogenous molecules into the extracellular milieu following loss of plasma membrane integrity. This model postulates that these endogenous molecules, referred ... -
The immunomodulatory properties of L-rhamnose
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)L-Rhamnose is a non-mammalian monosaccharide ubiquitously found on the surface of both commensal and pathogenic bacteria. Previous publications had identified that L-rhamnose-rich Mycobacterium tuberculosis glycolipids, ... -
An immunomodulatory role for indole-3-pyruvate, an excreted metabolite of the parasite Trypanosoma Brucei
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017)Human African trypanosomiasis, more commonly known as sleeping sickness, is one of the world's neglected diseases. Trypanosoma brucei, an extracellular parasitic protozoan of the genus Trypanosoma, is the causative agent. ... -
Immunomodulatory therapies for autoimmune diseases
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)Multiple sclerosis (MS) and psoriasis are both T cell mediated autoimmune diseases that are triggered in genetically susceptible individuals in response to environmental factors. Th17 cells are strongly implicated in the ... -
Immunopathological features of early age cancer: microsatellite instability in colorectal cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Title: Immunopathological features of early age cancer: microsatellite instability in colorectal cancer Background and hypothesis Deciphering the interplay between tumour biology and the immune system may aid the design ...