Browsing Biochemistry (Theses and Dissertations) by Title
Now showing items 57-76 of 290
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Delayed cell death in human and fish skin cell lines after exposure to UVA and UVB
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)The effects of ultraviolet radiation on humans and animals are receiving increasing attention and much interest has recently been focused on the environmental effects of UVA and UVB. This study compares the effects of UVA ... -
Delineating molecular mechanisms of inflammation-induced delirium using a novel mouse model
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Delirium is a syndrome of acute and transient confusion with disruption of attention and cognition; it is a common but underdiagnosed neuropsychiatric condition, which is predictive of increased fimctional decline, dementia ... -
Delineating the mechanisms utilised by Staphylococcus aureus to survive intracellularly within phagocytes
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Staphylococcus aureus (S. aureus) is a major human pathogen in addition to being an important part of the human microbiome. The bacterium has evolved a large array of immune evasion mechanisms to facilitate its persistence ... -
Dendritic cell mediated mucosal cross talk
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Developing efficacious vaccines against enteric diseases is a global challenge and priority. The rational design of such vaccines requires that novel pathways of cellular recruitment to the gastrointestinal (GI) tract be ... -
Derivation of dopaminergic neurons from embryonic and induced pluripotent stem cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Dopamine (DA) neurons have several fundamental functions in the brain, dysfunction of which has been implicated in neurological and psychiatric disorders, including Parkinson’s disease (PD) and schizophrenia. Embryonic ... -
Detection, expression and elucidation of the mechanism of action of mitochondrial uncoupling Protein 1
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)A system for overexpression of recombinant proteins in E. coli is defined. Using subcloning techniques the cDNAs for human uncoupling proteins (hUCP) 1, 2 and 3 were introduced to the pET expression system for E. coli. ... -
Development and application of novel virtual High Throughput Screening (vHTS) Technologies
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)The development of new pharmaceutical drugs is an expensive, timeconsuming task with an often low success rate. Traditionally, once a therapeutic target and its role in disease is identified, the process of identification ... -
Development of novel pyrrolo-1,5-benzoxazepines as anti-cancer agents for the treatment of chronic myeloid leukaemia
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Chronic myeloid leukaemia (CML) is characterised by the presence of a constitutively active tyrosine kinase known as Bcr-Abl. The Bcr-Abl kinase inhibitor, STI571, is the first line treatment for CML, but the recent emergence ... -
DHX9 : novel roles in cytokine induction and its antagonism by vaccinia virus protein E3
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Vaccinia virus (VACV) is a dsDNA virus, which replicates in the cytoplasm of infected host cells. VACV, similar to other viruses, is detected by host innate immunity mainly by sensing of viral nucleic acids such as dsRNA, ... -
Differential patterns of gene expression associated with metastasis in colon cancer
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)Metastatic spread is the main cause of colon cancer related death and therefore a greater understanding of this process is a prerequisite for improved treatment. The acquisition of metastatic properties confers tumour cells ... -
Differential patterns of gene expression associated with microsatellite instability and chromosomal instability in colorectal cancer
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)Two distinct pathways exist in sporadic colorectal cancer. The microsatellite instability pathway (MIN) is recognised by widespread instability caused by aberrant mismatch repair machinery. This genotype accounts for 15% ... -
Distinct local and systemic innate immune gene expression in response to Staphylococcus aureus-induced subclinical mastitis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Both local and systemic innate immune activity has a critical role in maintaining immunological homeostasis in the mammary gland. Dysregulation of the homeostatic process leads to increased infection and related pathology, ... -
Evaluation of the anti-cancer effects of novel pyrrolo-1, 5-benzoxazepines in neuroblastoma
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Neuroblastoma, a malignancy of neuroectodermal origin, accounts for 15% of childhood cancer deaths. Despite both advances in understanding the biology of the cancer and aggressive treatment strategies, it continues to be ... -
Evolution of human Natural Killer cell receptors
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)Natural Killer (NK) cells are key components of the innate immune system which function in identifying and destroying aberrant or infected cells. They also play active roles in human reproduction. These functions are largely ...