Browsing Biochemistry (Theses and Dissertations) by Title
Now showing items 39-58 of 290
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Cancer cell bioenergetics in response to anti-cancer agents
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Altered metabolism is a hallmark of cancer (Hanahan and Weinberg, 2011) and while genetic and molecular modifications have enabled cancers to survive the onslaught of various cancer therapies (Pillai et al., 2010), changes ... -
Characterisation of Innate Immune and Metabolic Roles of SARM1 in Mouse Macrophages.
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Engagement of the NLRP3 inflammasome in response to injury or infection results in the activation of the pro-inflammatory protease, caspase-1. Cleavage of the caspase-1 substrate, gasdermin D (GSDMD), leads to the GSDMD ... -
Characterisation of Membrane Glycoproteins that are Essential for Flagellar Attachment in the Bloodstream Form of Trypanosoma brucei
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)The African trypanosome, Trypanosoma brucei, is a unicellular parasitic protist that causes a severe disease, trypanosomiasis, in humans and livestock in sub-Saharan Africa. The trypanosome has a single flagellum that ... -
Characterisation of signalling pathways activated by the IL-1 receptor homologue T1/ST2
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2003)T1/ST2 is a member of the IL-1 receptor family possessing the three characteristic extracellular Ig domains and an intracellular Toll-IL1R (TIR) domain. It is an orphan receptor expressed on a variety of cell types including ... -
Characterisation of T cell responses during Staphylococcus aureus infection
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)The development of anti-S. aureus vaccines has consistently failed in clinical trials, likely due to inefficient induction of cellular immunity. A comprehensive understanding of the discrete T cell subsets critical for ... -
Characterisation of the immune response to calcium phosphate particulates; implications for osteoarthritis and bone tissue engineering
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Early trauma, resulting in focal areas of cartilage damage with injury to the underlying subchondral bone (osteochondral damage) often progresses to arthritis. These so called osteochondral defects (OCDs) can arise from ... -
Characterisation of the innate immune response to Campylobacter jejuni colonisation in the chicken intestine
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Campylobacter jejuni is the leading cause of gastroenteritis in humans, and chickens are the primary vector for infection. The microbe colonises the caeca of birds as a commensal, and it is hypothesised that intestinal ... -
Characterisation of the novel leucine rich repeat containing protein KIAA0644
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)This thesis reports the existence o f a novel leucine rich repeat containing protein annotated as KIAA0644 in the Kazusa DNA Research Institute database (www.Kazusa.or.jp). which was discovered in a study for proteins ... -
Characterisation of the role of Bruton's tyrosine kinase in toll-like receptor signalling
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)Toll-like receptors (TLRs) are the primary surveillance system for the detection of pathogens and are crucial to the activation of the host innate response. TLRs contain an extracellular leucine rich repeat region which ... -
Characterization of Staphylococcal protein A cellular interactions to facilitate its development as a vaccine antigen
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The development of a vaccine from bench to bedside is a lengthy and complex process, which is so rarely fully realized and followed throughout. During the course of this project, we have been able to follow the development ... -
Chitin-derived STING Activators as Adjuvants and Therapeutics
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)A significant challenge in the advancement of vaccine research is a lack of adjuvants that can safely drive potent cellular immunity against intracellular pathogens and cancer, a problem only exacerbated by our limited ... -
Chitosan based adjuvants promote proinflammatory Th1 and Th17 responses
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Particulate vaccine adjuvants, including alum and biodegradable polymer microparticles, are strong activators of antigen-specific humoral immunity. These particulates enhance NLRP3 inflammasome activation, but they are ... -
The circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)The response of the innate immune system to an inflammatory insult is largely dependent on time-of-day, and many inflammatory conditions are associated with dysfunctional molecular clocks within immune cells. However, the ... -
Citrate, oxaloacetate and 2-hydroxyglutarate in the control of inflammatory macrophage activation
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Immunometabolism is the study of changes that occur in the metabolic pathways of an immune cell during its activation. For macrophages, the remodelling of their metabolism following activation supports the adoption of ... -
Computational approaches to the display and manipulation of metabolic pathways : theory and practice
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)Since metabolic pathways constitute a complex system, a mathematical description, even a structural one, must be simplified. Yet, the model must be sufficiently general so that it will encompass the system that is to be ... -
CRISPR Gene Editing Approaches in the Study of Allergy and Infertility
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019) -
Cyclosporine A modulates CD103+ DC responses to fungal PAMPs
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Cyclosporine A (CsA) is an immunosuppressant that protects against inflammatory diseases and graft rejection. Despite its strong efficacy, one side-effect of CsA is an increased risk of fungal infection. To minimise this, ... -
Cytidine Aminohydrolase
The object of this work was to gain some information about the mechanics of action of cytidine aminohydralase from sheep liver -
Delayed cell death in human and fish skin cell lines after exposure to UVA and UVB
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)The effects of ultraviolet radiation on humans and animals are receiving increasing attention and much interest has recently been focused on the environmental effects of UVA and UVB. This study compares the effects of UVA ... -
Delineating molecular mechanisms of inflammation-induced delirium using a novel mouse model
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Delirium is a syndrome of acute and transient confusion with disruption of attention and cognition; it is a common but underdiagnosed neuropsychiatric condition, which is predictive of increased fimctional decline, dementia ...