Search
Now showing items 41-50 of 87
The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice.
(American Society for Biochemistry and Molecular Biology, 2003)
Increased production and deposition of the 40?42-
amino acid beta-amyloid peptide (Abeta) is believed to be central
to the pathogenesis of Alzheimer?s disease. A is
derived from the amyloid precursor protein (APP), ...
The Neuronal Adaptor Protein X11beta Reduces Amyloid beta-Protein Levels and Amyloid Plaque Formation in the Brains of Transgenic Mice*
(American Society for Biochemistry and Molecular Biology, 2004)
Accumulation of cerebral amyloid beta-protein (A beta) is
believed to be part of the pathogenic process in Alzheimer?s
disease. Abeta is derived by proteolytic cleavage from
a precursor protein, the amyloid precursor ...
Cigarette smoking and psychotic symptoms in bipolar affective disorder
(The Royal College of Psychiatrists, 2001)
Background An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology.
Aims To determine whether smoking is associated with psychosis in bipolar affective ...
The Depression Network (DeNT) Study: Methodology and Sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetics study
(BMC, 2004)
Background: The Depression Network Study (DeNt) is a multicentre study designed to identify
genes and/or loci linked to and/or associated with susceptibility to unipolar depression in Caucasian
families. This study ...
Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders.
(2011)
Recent genome-wide association studies (GWAS) have implicated a range of genes from discrete biological pathways in the aetiology of autism. However, despite the strong influence of genetic factors, association studies ...
A Randomized, Controlled Trial With 6-Month Follow-Up of Repetitive Transcranial Magnetic Stimulation and Electroconvulsive Therapy for Severe Depression
(American Psychiatric Association, 2007)
OBJECTIVE: Repetitive transcranial magnetic stimulation (rTMS) has been reported to be as effective as electroconvulsive therapy (ECT) for major depression. The authors conducted a multicenter randomized, controlled trial ...
Assessing neuronal networks: Understanding Alzheimer's disease
(2009)
Findings derived from neuroimaging of the structural and functional organization of the human brain have led to the widely supported hypothesis that neuronal networks of temporally coordinated brain activity across different ...
Serotonergic System and Attention Deficit Hyperactivity Disorder (ADHD): a potential susceptibility locus at the 5-HT1B receptor gene in 270 Trios from a multi-center sample
(2002)
Attention deficit hyperactivity disorder (ADHD) is a highly heritable and heterogeneous disorder, which usually becomes apparent during the first few years of childhood. Imbalance in dopamine neurotransmission has been ...
Whole genome linkage scan of recurrent depressive disorder from the depression network study
(Oxford University Press, 2005)
Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for ...