Browsing Psychiatry (Scholarly Publications) by Author "CORVIN, AIDEN PETER"
Now showing items 21-31 of 31
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Mental state decoding versus mental state reasoning as a mediator between cognitive and social function in psychosis
CORVIN, AIDEN PETER; DONOHOE, GARY (JAMES); GILL, MICHAEL; McGlade, Nicola; Behan, Caragh; Hayden, Judy; O'Donoghue, Therese; Peel, Rosie; Haq, Farhan; O'Callaghan, Eadbhard (2008)Theory of mind deficits in schizophrenia have been parsed into mental state reasoning and mental state decoding components. We report that mental state decoding as measured by the `Eyes task? better predicted social ... -
Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia.
CORVIN, AIDEN PETER (2012)With the recent success of genome-wide association studies (GWAS), a wealth of association data has been accomplished for more than 200 complex diseases/traits, proposing a strong demand for data integration and interpretation. ... -
The NOS1 variant rs6490121 is associated with variation in prefrontal function and gray matter density in healthy individuals
FRODL, THOMAS; DONOHOE, GARY (JAMES); GILL, MICHAEL; CORVIN, AIDEN PETER; NEWELL, FIONA; ROSE, EMMA; FAHEY, CIARA; GARAVAN, HUGH PATRICK; BOKDE, ARUN LAWRENCE WARREN; O'DOHERTY, JOHN PHILIP; MC GRATH, JANE; KELLY, SINEAD; ROBERTSON, IAN H; MORRIS, DEREK (Elsevier, 2012)A common polymorphism within the nitric oxide sythanse-1 (NOS1) gene (rs6490121), initially identified as risk variant for schizophrenia, has been associated with variation in working memory and IQ. Here we investigated ... -
Rare chromosomal deletions and duplications increase risk of schizophrenia.
CORVIN, AIDEN PETER; MORRIS, DEREK (2008)Schizophrenia is a severe mental disorder marked by hallucinations, delusions, cognitive deficits and apathy, with a heritability estimated at 73-90% (ref. 1). Inheritance patterns are complex, and the number and type of ... -
Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.
MORRIS, DEREK; GILL, MICHAEL; CORVIN, AIDEN PETER (2012)Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but ... -
The SNP ratio test: pathway analysis of genome-wide association datasets
MORRIS, DEREK; HERON, ELIZABETH ANN; CORVIN, AIDEN PETER; GILL, MICHAEL; O'Dushlaine, Colm; Kenny, Elaine; Segurado, Ricardo (2009)Summary: We present a tool that assesses the enrichment of significant associations from genome-wide association studies (GWAS) in a pathway context. The SNP ratio test (SRT) compares the proportion of significant to ... -
Social dysfunction in schizophrenia: An investigation of the GAF scale's sensitivity to deficits in social cognition.
MORRIS, DEREK; HARGREAVES, APRIL; CORVIN, AIDEN PETER; GILL, MICHAEL; ROBERTSON, DEIRDRE; DONOHOE, GARY (JAMES) (2013)BACKGROUND: Schizophrenia is accompanied by significant impairment in psychosocial functioning, which is only partially explained by clinical symptom severity. Recently, these impairments have been strongly associated ... -
Two patients walk into a clinic...a genomics perspective on the future of schizophrenia.
CORVIN, AIDEN PETER (BioMed Central, 2011)Progress is being made in schizophrenia genomics, suggesting that this complex brain disorder involves rare, moderate to high-risk mutations and the cumulative impact of small genetic effects, coupled with environmental ... -
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.
CORVIN, AIDEN PETER (2012)Genome-wide association studies (GWASs) have been successful at identifying single-nucleotide polymorphisms (SNPs) highly associated with common traits; however, a great deal of the heritable variation associated with ... -
The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report
CORVIN, AIDEN PETER; GILL, MICHAEL; SEGURADO, RICARDO (Nature Publishing Group, 2002)We have completed the first stage of a two-stage genome wide screen designed to identify chromosomal regions that may harbour susceptibility genes for bipolar affective disorder. The first stage screening sample included ... -
ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia
CORVIN, AIDEN PETER; ROSE, EMMA; DONOHOE, GARY (JAMES); FRODL, THOMAS; MORRIS, DEREK; GILL, MICHAEL (Elsevier, 2010)ZNF804A rs1344706 is the first genetic risk variant to achieve genome wide significance for psychosis. Following earlier evidence that patients carrying the ZNF804A risk allele had relatively spared memory function compared ...