Browsing Clinical Microbiology (Theses and Dissertations) by Title
Now showing items 1-20 of 28
-
A role for proteases and transcriptional regulation in the expression of ClfB on the surface of staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2002)Staphylococcus aureus is an important human pathogen. This bacterium expresses proteins on its surface capable of binding to many host ligands including fibrinogen, fibronectin, collagen, elastin and von Willebrand factor. ... -
Analysis and development of the recombinant Semliki Forest virus vector as a cancer gene therapy agent
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2001)Increased understanding of the molecular pathogenesis of cancer has shown that its accumulation is the result of multiple genetic alterations. Cancer is a disease of altered genes, with the most predominantly altered ... -
Anti-infective strategies in Pseudomonas aeruginosa biofilm formation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2014)P. aeruginosa infection is one of the main causes of lung function decline in patients with cystic fibrosis (CF). P. aeruginosa is associated with biofilm formation which can increase the rate of resistance to antibiotic ... -
Antimicrobial resistance and virulence in Escherichia coli bloodstream isolates : a phenotypic, genetic and genomic perspective
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2010)Extraintestinal pathogenic Escherichia coli (ExPEC) are a major cause of sepsis, with a high associated mortality. They are widely reported to be the most frequent Gram-negative bacterial pathogen recovered from bacteraemia ... -
Antimicrobial resistance in clinical isolates of Pseudomonas aeruginosa
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2011)Pseudomonas aeruginosa is one of the most feared Gram-negative bacterial pathogens. It is not only among the most frequently isolated Gram-negative organisms in bloodstream and wound infections, pneumonia, intra-abdominal-sepis ... -
Characterisation and Molecular Epidemiology of Mycobacterium chimaera isolates in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2019)Mycobacterium chimaera is a slow-growing nontuberculous Mycobacterium spp. that is now recognized as a separate species within the Mycobacterium avium Complex (MAC). In the past, M. chimaera was mainly associated with ... -
Characterisation of the Elastin Binding Protein (EbpS) of Staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2001)Staphylococcus aureus expresses an array of surface proteins that promote interaction of the bacterium with the host. Some surface proteins promote binding to components of the host extracellular matrix and can act as ... -
Development of the recombinant Semliki Forest virus vector as a gene therapy agent for the central nervous system
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2004)Multiple sclerosis (MS) is a neurological disease of the central nervous system (CNS), and a major cause of disability in young adults. It is characterized by the presence of inflammatory infiltrates containing autoreactive ... -
Diverse Roles for the Extracellular Glycome of Extra-intestinal Pathogenic Escherichia coli in Serum Resistance and more
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2023)Extra-intestinal pathogenic Escherichia coli (ExPEC) is a major cause of urinary tract infections, bacteraemia, and sepsis. This laboratory, among others, has previously shown that prototypic urosepsis strain CFT073 is ... -
Evaluating the role of angiogenesis in disease behaviour and therapy response in ulcerative colitis
Introduction Ulcerative colitis (UC) is a chronic inflammatory condition with a significant impact on quality of life. In this thesis two small molecule anti-angiogenic and anti-inflammatory agents were used to treat tissue ... -
Evaluation of an in-house six-well screening plate as a means of detecting phenotypic triazole resistance in St. James's Hospital, Dublin with emphasis on Aspergillus fumigatus
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2022)Aspergillus fumigatus is a ubiquitous saprophytic mould fungus found in nature. This fungus is present in the air, in soil, in foliage in our food stock and on inanimate surfaces. For healthy individuals, A. fumigatus poses ... -
Evaluation of Next-Generation Sequencing to Investigate the Epidemiology of Clostridioides difficile Infection
Introduction: Clostridioides difficile (C. difficile) is an anaerobic bacteria, which can cause gastrointestinal infection. There are approximately 2,000 cases of C. difficile infection (CDI) diagnosed in Ireland per year, ... -
Functional analysis of the VirB protein of Shigella flexneri
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2003)The VirB protein is a key regulator of virulence gene expression in Shigella flexneri, a facultative enteroinvasive pathogen that causes bacillary dysentery. Genetic evidence has shown that VirB is required for the activation ... -
Inhibition of K-BALB murine tumours using Semliki Forest virus and its derived factor
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2005)The induction of cytopathic effects in tumour cells, often by apoptosis, is the primary goal of most non-surgical cancer therapies. Cancer gene therapy represents a variety of potentially therapeutic strategies involving ... -
Investigating the Role of Extracellular Polysaccharides in Biofilm Formation of Klebsiella pneumoniae
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2020)Klebsiella pneumoniae (K. pneumoniae) is the most significant and clinically relevant species in the Klebsiella genus of Enterobacteriaceae and is the causative agent of a variety of infections, including pneumonia, urinary ... -
Investigation of reduced susceptibility to glycopeptides among meticillin-resistant Staphylococcus aureus recovered in Ireland (1998-2004)
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2009)Meticillin-resistant Staphylococcus aureus (MRSA) isolates (n=3,189) from 2990 patients were studied by agar screening and the E-test™ macromethod to investigate reduced susceptibility to glycopeptides among six collections ... -
Investigation of the pathogenicity of Rubella virus for the central nervous system
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2002)Rubella virus (RV) is the cause of a mild self limiting disease, known as German measles, which predominates during childhood. It is however the devastating teratogenic effects of this virus that are of most concern. Rare ... -
Investigations of Aspergillus infection in Cystic Fibrosis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2015)Aspergillus fumigatus is a ubiquitous saprophytic fungus that is a pathogen in principally immunocompromised hosts. It is the most common fungal pathogen in Cystic Fibrosis (CF), most often associated with Allergic ... -
Molecular characterisation of carbapenem resistance of Acinetobacter species in an Irish tertiary care hospital
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2010)This study was undertaken with the primary aim of characterising the molecular epidemiology and mechanisms of resistance to carbapenems in Acinetobacter isolates collected at St. James’s Hospital, Dublin. -
Molecular characterisation of the interactions between staphylococcus aureus and elastin
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2002)Previous studies have shown that a cell-surface 83 kDa elastin-binding protein of Staphylococcus aureus (EbpS) mediates binding to soluble elastin. Antibodies were produced to the N terminus and C terminus of EbpS. Western ...