Browsing Clinical Microbiology (Theses and Dissertations) by Title
Now showing items 14-28 of 28
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Inhibition of K-BALB murine tumours using Semliki Forest virus and its derived factor
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2005)The induction of cytopathic effects in tumour cells, often by apoptosis, is the primary goal of most non-surgical cancer therapies. Cancer gene therapy represents a variety of potentially therapeutic strategies involving ... -
Investigating the Role of Extracellular Polysaccharides in Biofilm Formation of Klebsiella pneumoniae
(Trinity College Dublin. School of Medicine. Discipline of Clinical Microbiology, 2020)Klebsiella pneumoniae (K. pneumoniae) is the most significant and clinically relevant species in the Klebsiella genus of Enterobacteriaceae and is the causative agent of a variety of infections, including pneumonia, urinary ... -
Investigation of reduced susceptibility to glycopeptides among meticillin-resistant Staphylococcus aureus recovered in Ireland (1998-2004)
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2009)Meticillin-resistant Staphylococcus aureus (MRSA) isolates (n=3,189) from 2990 patients were studied by agar screening and the E-test™ macromethod to investigate reduced susceptibility to glycopeptides among six collections ... -
Investigation of the pathogenicity of Rubella virus for the central nervous system
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2002)Rubella virus (RV) is the cause of a mild self limiting disease, known as German measles, which predominates during childhood. It is however the devastating teratogenic effects of this virus that are of most concern. Rare ... -
Investigations of Aspergillus infection in Cystic Fibrosis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2015)Aspergillus fumigatus is a ubiquitous saprophytic fungus that is a pathogen in principally immunocompromised hosts. It is the most common fungal pathogen in Cystic Fibrosis (CF), most often associated with Allergic ... -
Molecular characterisation of carbapenem resistance of Acinetobacter species in an Irish tertiary care hospital
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2010)This study was undertaken with the primary aim of characterising the molecular epidemiology and mechanisms of resistance to carbapenems in Acinetobacter isolates collected at St. James’s Hospital, Dublin. -
Molecular characterisation of the interactions between staphylococcus aureus and elastin
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2002)Previous studies have shown that a cell-surface 83 kDa elastin-binding protein of Staphylococcus aureus (EbpS) mediates binding to soluble elastin. Antibodies were produced to the N terminus and C terminus of EbpS. Western ... -
Molecular epidemiology, cluster analysis, and drug resistance prediction of Mycobacterium tuberculosis complex in Ireland using conventional methods and Whole Genome Sequencing
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2017)Tuberculosis (TB), caused by Mycobacterium tuberculosis Complex (MTBC), is the joint leading cause of death worldwide due to a single infectious agent, with HIV/AIDS, and remains a major challenge to public health in both ... -
Plasmodium falciparum aminopeptidases and their role in haemoglobin degradation in malaria-infected erthrocytes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2001)Malaria remains one of the world's most important infectious diseases. There is no vaccine available, and the spread of drug resistance has narrowed the choice of chemotherapy, especially for the most lethal human malaria ... -
Regulation of Antigen 43, a phase-variable autoaggregation factor of Escherichia coli
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2003)The Antigen 43 protein (Ag43) of Escherichia coli, encoded by the agn43 gene, has previously been shown to be expressed in a phase-variable manner. A plasmidborne fusion of the agn43 regulatory region to the reporter gene ... -
StpA and the regulation of OmpF porin expression in Escherichia coli
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2001)When the proteomic profile of a wild-type strain of Escherichia coli and its stpA hns mutant derivative were compared by two-dimensional gel electrophoresis, the levels of expression of several proteins were altered. One ... -
The control of DNA gyrase expression and its role in deletion formation in Salmonella enterica
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2003)Salmonella typhimurium strain CJD671 can undergo the deletion of a 5kb segment of DNA from its large virulence plasmid. This results in a transcriptional fusion between the rlgA gene, encoding a putative site-specific ... -
The molecular characterization of the clumping Factor A (ClfA) from Staphylococcus aureus using monoclonal antibodies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2000)Clumping factor (ClfA) of Staphylococcus aureus is the major fibrinogen- binding adhesin located on the cell surface of the bacterium. Monoclonal antibodies (mAbs) were produced to two recombinant truncated ClfA proteins, ... -
The role of beta-lactamase in low-level cephalosporin-resistant serratia marcescens
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2002)In enterobacteria, high-level cephalosporin resistance is commonly mediated by constitutive over-production or derepression of chromosomal AmpC β-lactamase. This derepression is frequently associated with mutations in ... -
The role of the Salmonella PagN protein in adhesion and invasion
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2015)Salmonella, an important genus of Gram-negative enteric bacteria, is the causative agent of many different diseases including Typhoid Fever and Gastroenteritis. Salmonella utilises multiple methods of invading mammalian ...