Browsing Physiology (Scholarly Publications) by Author "COSTELLO, DEREK"
Now showing items 1-5 of 5
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Dok2 mediates the CD200Fc attenuation of Aß-induced changes in glia.
LYNCH, MARINA; MURPHY, NIAMH; COSTELLO, DEREK; DOWNER, ERIC (2012)Background: The interaction between the membrane glycoprotein, CD200 and its cognate receptor CD200 receptor (CD200R), has been shown to play a role in maintaining microglia in a quiescent state. There is evidence of ... -
Glial Activation in A?PP/PS1 Mice is Associated with Infiltration of IFN?-Producing Cells.
LYNCH, MARINA ANNETTA; COSTELLO, DEREK; MINOGUE, AEDIN (2013) -
SIGIRR modulates the inflammatory response in the brain
COSTELLO, DEREK; LYNCH, MARINA ANNETTA; MC QUILLAN, KEITH (Elsevier, 2010)One of the more recently described members of the interleukin-1 (IL-1) receptor family, single-Ig-Interleukin-1 related receptor (SIGIRR), has been identified as a negative regulator of inflammation in several tissues. ... -
Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β
COSTELLO, DEREK; LYNCH, MARINA (2013)The family of toll-like receptors (TLR) plays a major role in innate immunity due to their pathogen-recognition abilities. TLR3 is a sensor for double-stranded RNA, and regulates host-defense responses to several viruses, ...